Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases.

Syndecan-1 (Sdc1) is a transmembrane heparan sulfate proteoglycan, an extracellular matrix receptor involved in intercellular communication, proliferation, angiogenesis, and metastasis. This study determined and compared Sdc1 expression in the tumor cells and stroma of 30 invasive lobular and 30 invasive ductal breast carcinomas (ILCs/IDCs), also in the axillary node metastases of ductal type, and correlated it with clinical and tumor parameters. Sdc1 was expressed in the epithelium of 90% carcinoma of both histological types.

Obstructive Jaundice as an Uncommon Manifestation of Metastatic Breast Cancer.

Invasive ductal carcinoma is the most common type of breast cancer and accounts for about 70-85% of all invasive breast carcinomas. It primarily metastasizes to the bone, lungs, regional lymph nodes, liver and brain. Most of breast cancer recurrence occurs within the first 5 years of diagnosis, particularly for ER negative disease.

Histologic subtypes of invasive lobular carcinoma in correlation with tumor status and hormone receptors.

Invasive lobular carcinoma is a distinct biological entity with several histologic variants the prognostic value of which is not fully elucidated. The aim of this study was to determine the immunohistochemical expression of estrogen receptors (ER) and progedterone receptors (PR) in subtypes of lobular breast carcinoma (classic and variant types) and to correlate them with clinical and tumor parameters. Fifty lobular carcinomas, i.