Publications by authors named "I Ming Shih"
Background: Targeting glutamine metabolism has emerged as a promising strategy in cancer therapy. However, several barriers, such as anti-tumor efficacy, drug toxicity, and safety, remain to be overcome to achieve clinical utility. Prior preclinical studies had generated encouraging data showing promises of cancer metabolism targeting drugs, although most were performed on immune-deficient murine models.
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- * Patients undergoing MIP experienced better perioperative outcomes than those who had OS for non-PD, including shorter hospital stays and fewer complications, while outcomes for PD were similar for both methods.
- * The robotic-assisted surgery (RS) approach showed a lower rate of conversion to open surgery compared to laparoscopic surgery (LS) in both PD and non-PD cases, and MIP has gained traction in non-PD procedures while showing stagnant adoption rates for PD.
Objective: Increased glutamine metabolism by cancer cells via upregulation of the drug-targetable enzyme glutaminase may contribute to an immune-suppressive tumor microenvironment. Inhibiting glutamine metabolism can not only suppress tumor growth, but also enhance tumor-specific immunity. We investigated the relationship between glutaminase expression, the immune tumor microenvironment, and clinicopathologic features in endometrial cancer.
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- The APDCRS has been running a standardized robotics course for colorectal fellows since 2011, aimed at improving surgical techniques in minimally invasive surgery.* -
- A survey of colorectal surgery graduates from 2014-2022 revealed that the majority had significant experience with laparoscopic and robotic surgeries, with an increasing trend in robotic case volumes over time.* -
- A large percentage of respondents (88.6%) felt that the course met their expectations and prepared them for using robotic techniques in their post-fellowship practices.*
Article Synopsis
- High-grade serous carcinomas (HGSC) primarily originate from fallopian tube precursors, but some arise through a different pathway linked to low-grade serous ovarian neoplasms.
- Research involving whole exome sequencing of low-grade and higher-grade components revealed distinct mutation patterns, with fewer shared mutations between the two, indicating a complex evolutionary process.
- The transformation to HGSC often involves TP53 mutations and is associated with severe cellular abnormalities; however, some tumors with wild-type TP53 show diverse morphological characteristics and less chromosomal instability.