Publications by authors named "I Miller"
Radiotherapy is used to treat over 50% of cancer patients. It is often used in combination with surgery, chemotherapy, and immunotherapy, for cancers of the breast, lung, oesophagus, and rectum. Ionising radiation predominantly exerts its anti-cancer effect through both direct DNA damage and indirectly via water radiolysis and the production of reactive oxygen species.
View Article and Find Full Text PDFPurpose: With increases in precision medicine initiatives and genetically defined rare diseases, the genetics and metabolism workforce is necessary to provide around-the-clock care for patients. Here, we describe the impact that home-based call has on the geneticist and metabolist workforce.
Methods: Physicians from 3 populations were self-identified (pediatric subspecialist, geneticist, metabolist) and completed a survey regarding the impact of home-based call service on their sleep and wellness.
Fearing Meningitis: Disease, Emotions and the Spotted Fever Epidemics of 1904-1907.
J Hist Med Allied Sci
December 2024
The meningitis (or spotted fever) outbreaks (c.1904-1907) caused worldwide alarm but remain largely forgotten. This article uses these outbreaks as an invaluable case study for understanding early twentieth-century responses (individual and collective) to a mysterious, potentially deadly infection.
View Article and Find Full Text PDFArticle Synopsis
- vB_KquU_φKuK6 is a bacteriophage that infects multidrug-resistant bacterial strains and shows potential for phage therapy despite being a temperate phage.
- The phage's structure includes a complex capsid and a genome with genes essential for lytic and lysogenic infections, along with properties that indicate stability across various conditions.
- While vB_KquU_φKuK6 can reduce biofilm formation and enhance the effectiveness of certain antibiotics, it cannot be used directly for therapy due to its nature but could be valuable when modified or used alongside treatments.