[Expression of p53, Ki-67, bcl-2, c-erb-2, estrogen, and progesterone receptors in endometrial cancer].

Objective: To assess the immunohistochemical expression of p53, bcl-2, c-erb-2, Ki-67, estrogen and progesterone receptors in endometrial cancer patients.

Design: Experimental study.

Setting: Department of Obstetrics and Gynecology, Institute of Human Genetics, Department of Pathology, Palacky University Medical School and University Hospital, Olomouc.

[Advanced maternal age as an indication for invasive prenatal diagnostics?].

Objectives: To investigate the effectivity of the first trimester screening (FTS), age and other factors as an indication for invasive testing.

Methods: A retrospective analysis of indications for invasive procedures and their effectivity in the group of women who underwent screening in the first trimester of pregnancy in our center. Women were offered the combined screening program by ultrasound and biochemical markers.

[Efficiency of measuring nasal bone as an ultrasound marker of Down syndrome in 11th to 13th+6 week of pregnancy].

Objectives: The aim of this study is to evaluate the significance of nasal bone as a marker for trisomy 21 in the group of women that underwent invasive procedures in our center at 11 to 14 weeks' gestation.

Methods: The data of 181 women who had undergone the invasive procedures were evaluated for the presence or absence of nasal bone retrospectively and were correlated with fetal karyotype.

Results: A successful view of the fetal profile was obtained in 135 fetuses.

Single umbilical artery and its siding in the second trimester of pregnancy: relation to chromosomal defects.

Objectives: To determine the possible association between single umbilical artery (SUA) in the second trimester of pregnancy and the incidence of chromosomal abnormalities. To determine whether the presence of chromosomal defects in fetuses with SUA is related to the side of the missing artery.

Methods: Color flow imaging of the fetal pelvis was used to determine the number of umbilical arteries in 2147 fetuses immediately before amniocentesis for karyotyping in the second trimester of pregnancy.

[Preoperative assessment of myometrial invasion in endometrial cancer patients by ultrasonography and magnetic resonance imaging (MRI)].

Objective: To compare the accuracy of transvaginal sonography and magnetic rezonance imaging (MRI) in determining the depth of myometrial invasion in proven cases of endometrial cancer.

Design: A prospective study.

Setting: Department of Obstetrics and Gynecology, Department of Medical Genetics and Fetal Medicine, Department of Radiology, University Hospital, Olomouc.