A Simple Machine Learning-Based Quantitative Structure-Activity Relationship Model for Predicting pIC Inhibition Values of FLT3 Tyrosine Kinase.

Acute myeloid leukemia (AML) presents significant therapeutic challenges, particularly in cases driven by mutations in the FLT3 tyrosine kinase. This study aimed to develop a robust and user-friendly machine learning-based quantitative structure-activity relationship (QSAR) model to predict the inhibitory potency (pIC values) of FLT3 inhibitors, addressing the limitations of previous models in dataset size, diversity, and predictive accuracy. Using a dataset which was 14 times larger than those employed in prior studies (1350 compounds with 1269 molecular descriptors), we trained a random forest regressor, chosen due to its superior predictive performance and resistance to overfitting.

Chronic mucocutaneous candidiasis, mycobacterial infections and rosacea in a Mexican adult with STAT1 gain of function.

STAT1 is a cytoplasmic transcription factor associated with cell growth regulation, differentiation, proliferation, metabolism, and apoptosis. IFN-mediated JAK/STAT signaling pathway is involved in eliminating intracellular pathogens and viruses. However, pathogenic variants in STAT1 can result in impaired or increased function.

First pilot study for newborn screening of severe T and B lymphopenias in Colombia.

Introduction: Congenital lymphopenias cause increased susceptibility to infections in children apparently healthy at birth. Earlier detection of these conditions would facilitate prompt treatment, prevent potentially serious disease complications and early deaths, and save healthcare resources.

Objective: To perform a pilot study for neonatal screening of congenital lymphopenias by the quantification of TREC and KREC –T- and B-cell receptor excision circles– in peripheral blood samples from newborns in Medellín, Colombia.

Essential oils from Colombian Croton spp. exhibit antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and ampicillin- and streptomycin-resistant Escherichia coli.

Bacterial resistance, a global public health concern prioritized by the World Health Organization, is particularly alarming in Staphylococcus aureus and Escherichia coli. Urgently addressing this, the search for new antibiotics has turned to plant essential oils. Our study focused essential oils derived from Colombian plants Croton killipianus, Croton smithianus, Croton leptostachyus, Croton hondensis, and Croton gossypiifolius.

Partial or Focal Brachytherapy for Prostate Cancer: A Systematic Review and Meta-Analysis.

Introduction: Recent advances in image-guided brachytherapy have allowed for treatment volume reduction in the treatment of prostate cancer, with the aim to optimize disease control and reduce toxicities. This systematic review reports on the efficacy and safety of focal brachytherapy for treatment of patients with localized prostate cancer.

Methods: Medline, Embase, Web of Science and Cochrane were searched from inception to July 2023.