Publications by authors named "I McNamara"
Introduction: Rates of opioid overdose deaths (OOD) have increased since the introduction of illicitly manufactured fentanyl in the U.S. drug supply.
View Article and Find Full Text PDFBackground: Staphylococci cause a wide range of infections, including implant-associated infections which are difficult to treat due to the presence of biofilms. Whilst some proteins involved in biofilm formation are known, the differences in biofilm production between staphylococcal species remains understudied. Currently biofilm formation by Staphylococcus aureus is better understood than other members of the genus as more research has focused on this species.
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- Tibial plateau fractures are complex knee injuries that are challenging to treat, often requiring surgical fixation and sometimes bone defect fillers, but there is no established best practice for either approach.
- The study aimed to evaluate the effectiveness and potential risks of various surgical methods and filler materials for these fractures by analyzing data from randomized controlled trials and quasi-RCTs.
- Ultimately, 15 trials with 948 adult participants were included, focusing on outcomes like quality of life, limb function, and the rate of complications such as reoperations.
Article Synopsis
- GRN mutations lead to a condition known as FTD-GRN, which causes frontotemporal dementia; PR006 is a new gene therapy aimed at delivering the granulin gene using an adeno-associated virus.
- In initial studies, PR006 showed effectiveness in improving various pathological conditions related to FTD-GRN in animal models and was generally well tolerated in non-human primates.
- An ongoing human trial has reported that PR006 was safe for administration with some transient increases in progranulin levels in cerebrospinal fluid, although some patients experienced treatment-related adverse events, such as CSF pleocytosis and deep vein thrombosis.
Article Synopsis
- * Research suggests that biological factors, like altered brain responses to pain and low levels of natural painkillers (endogenous opioids), may explain the link between BPD and pain dysregulation.
- * The study emphasizes that emotional regulation plays a crucial role in how physical pain is experienced in BPD, affected by psychological factors and hindrances in patient-provider relationships that can complicate treatment for chronic pain.