Publications by authors named "I McL Welch"
Background: There are limited data on the effects of therapeutic anticoagulation (AC) on stroke and bleeding risk in patients with sepsis-induced atrial fibrillation (AF).
Objective: This study aimed to determine the effect of therapeutic AC on the development of inpatient strokes and significant bleeding in hospitalized patients with septic shock and AF.
Methods: This single-center, retrospective study examined 604 patients with septic shock and AF.
Article Synopsis
- * The study developed a rat model using N1S1 hepatoma cells to better understand tumor growth and test new treatments, observing tumor formation within days and varying tumor take rates across rat types.
- * Results suggest that immunocompetent SD rats show inconsistent tumor regression, making them unsuitable for therapy research, while immunosuppressed RNU rats provide reliable tumor growth for future investigations.
Development of a unilateral porcine emphysema model induced by porcine pancreatic elastase.
J Appl Physiol (1985)
November 2023
Emphysema is one of the pathological hallmarks of chronic obstructive pulmonary disease. We have recently reported that radiofrequency therapy improves lung function in rodent models of emphysema. However, preclinical data using large animals is necessary for clinical translation.
View Article and Find Full Text PDFApocynin reduces dihydroethidium fluorescence in naked mole-rat cortex independently of NADPH oxidase.
Comp Biochem Physiol A Mol Integr Physiol
February 2023
Pharmacological agents that modulate cellular targets offer a powerful approach to interrogate the role of a given component in cellular signalling cascades. However, such drugs are often nonspecific and/or have unexpected off-target effects. One cellular target of interest is the NADPH oxidase (NOX) enzyme family, which consume oxygen and produce reactive oxygen species.
View Article and Find Full Text PDFArticle Synopsis
- Recent research highlights that viral elements in the gut microbiota play a role in maintaining intestinal balance and protecting against inflammation and infections.
- The study focused on a specific murine norovirus (MNV; strain CR6) and found that the protein STAT1 is crucial for controlling viral replication and T cell immune responses, while also preventing damage from viral infections.
- Interestingly, even when T cell responses were impaired in mice lacking STAT1, the depletion of these immune cells did not worsen the disease caused by the virus, indicating that managing viral replication is more important for preventing illness than regulating T cell responses.