Publications by authors named "I McGowan"
Background: Problems in children's early social and emotional development are likely to have major long-term consequences for the individual and society: maternal emotional well-being is associated with better outcomes. Interventions designed to improve both maternal mental health and the mother-child relationship are thus likely to benefit both maternal health and child development.
Objectives: To establish the clinical and cost-effectiveness of the Mellow Babies parenting intervention for women experiencing psychosocial stress and their 6- to 18-month-old babies.
Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy.
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- The study examined the effects of vedolizumab in combination with antiretroviral therapy (ART) on HIV-1 spread after stopping ART in new HIV-1 infections.
- Participants were given monthly vedolizumab infusions before halting ART, and despite the treatment being safe, no one achieved undetectable HIV levels after 24 weeks off ART.
- The results indicated that blocking the α4β7 protein may play a key role in reducing the HIV-1 reservoir, suggesting it could be important for future HIV cure strategies.