Publications by authors named "I Matsushita"
Purpose: To determine the ultra-widefield fluorescein angiographic (UWFA) characteristics of patients with mild familial exudative vitreoretinopathy (FEVR) who had been confirmed to have pathogenic variants of the autosomal dominant (AD) genes of FEVR.
Design: Single center, observational case series.
Subjects And Controls: Thirty-seven patients with mild FEVR from 27 families who had pathogenic variants of the Norrin/β-catenin genes were studied.
Background: In walking in healthy adults, rotation of the hip joint affects stride length and shifts the center of gravity, but these are not seen in hip osteoarthritis which affects gait. In gait of total hip arthroplasty, there are few reports on changes in the horizontal plane. This study clarified the preoperative and early postoperative gait characteristics of patients undergoing total hip arthroplasty.
View Article and Find Full Text PDFPurpose: To assess the safety and efficacy of ripasudil for retinopathy of prematurity (ROP).
Study Design: Phase 1/2, multicenter, open-label, single-arm, 12-week clinical trial.
Methods: Infants born with gestational age (GA) of ≤ 32 weeks or weight of ≤ 1500 g with zone I or II, ≥ stage 1, ROP in both eyes were enrolled.
Article Synopsis
- The study aimed to explore the clinical characteristics of familial exudative vitreoretinopathy (FEVR) linked to either the Norrin or β-catenin genes, analyzing data from 281 subjects.
- Researchers utilized whole-exome sequencing and Sanger sequencing to assess genetic variants and their association with clinical symptoms in FEVR patients.
- The results indicated that a significant portion of probands with pathogenic variants showed more severe disease characteristics, including familial patterns of inheritance, rapid progression during infancy, and higher asymmetry in eye severity compared to those without these variants.
Article Synopsis
- * A majority of respondents indicated that over half of newly diagnosed patients were 65 or older, with a focus on achieving remission or low disease activity, while also prioritizing patient safety.
- * Rheumatologists expressed concern about comorbidities and other factors that could interfere with optimal treatment, indicating a more complex management landscape for older patients with LORA.