Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice.

In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized knockout mice. APOA1 is a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, and thus HDL; our recent work showed that deficiency of APOA1 increases bone marrow adiposity in mice. We found that deficient mice have greatly elevated adipocytes within their bone marrow compared to wild type counterparts.

High resolution computed tomography in fibrosing alveolitis associated with systemic sclerosis.

Objective: To investigate the use of high resolution computed tomography (HRCT) in diagnosis of patients with fibrosing alveolitis associated with systemic sclerosis (FA-SSc), and to determine predictors of disease progression.

Methods: We retrospectively studied 90 patients with SSc who had undergone an initial (Time 1) and followup (Time 2) clinical and HRCT evaluation, with a mean +/- SD interval of 5.14 +/- 2.

Asbestos-related pleuropulmonary diseases: evaluation with low-dose four-detector row spiral CT.

Purpose: To evaluate the depiction of lung and pleural asbestos-related lesions with low-dose four-detector row spiral computed tomography (CT).

Materials And Methods: Eighty-three male workers with a mean duration of occupational exposure to asbestos of 18 years underwent CT as part of a medicolegal investigation. CT examination included low-dose multi-detector row spiral CT of the entire thorax, with reconstruction of contiguous 5-mm-thick images, and thin-section CT, which served as the reference standard for the detection of pleural and parenchymal asbestos-related abnormalities.

Multi-detector row spiral CT angiography of the thoracic outlet: dose reduction with anatomically adapted online tube current modulation and preset dose savings.

Purpose: To evaluate image quality obtained with anatomically adapted online tube current modulation and preset minimum dose savings at multi-detector row spiral computed tomographic (CT) angiography of the thoracic outlet.

Materials And Methods: A total of 100 patients were evaluated for thoracic outlet arterial syndrome with spiral CT angiography (collimation, 4 x 1 mm; pitch, 1.75) both with and without dose reduction by means of anatomically adapted online tube current modulation and preset minimum dose savings.

Pulmonary embolus imaging with multislice CT.

Multiple data support the concept that single-slice and multislice CT have fundamentally modified the diagnostic approach of patients with suspected PE. Although the definitive role of spiral CT angiography in the diagnostic algorithm has yet to be determined, it is clear that CT angiography has numerous advantages compared with other diagnostic tests. Bearing in mind that an effective diagnostic strategy should be as flexible as possible to be applied in every clinical setting, the role of spiral CT angiography in the diagnostic algorithm has to be considered among several practical parameters, such as the experience of the attending physician, degree of severity of the patient's clinical condition, the availability of diagnostic equipment, and specific logistics.