Publications by authors named "I Mantel"
Macrophages are key drivers of inflammation and tissue damage in autoimmune diseases including rheumatoid arthritis. The rate-limiting step for transcription of more than 70% of inducible genes in macrophages is RNA polymerase II (Pol II) promoter-proximal pause release; however, the specific role of Pol II early elongation control in inflammation, and whether it can be modulated therapeutically, is unknown. Genetic ablation of a pause-stabilizing negative elongation factor (NELF) in macrophages did not affect baseline Pol II occupancy but enhanced the transcriptional response of paused anti-inflammatory genes to lipopolysaccharide followed by secondary attenuation of inflammatory signaling in vitro and in the K/BxN serum transfer mouse model of arthritis.
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- Diabetic macular edema (DME) is a serious vision impairment often treated with anti-VEGF agents, but some patients don't respond well; this study tests the effectiveness of the intravitreal dexamethasone (DEX) implant as a second-line option for those not responding adequately or facing high treatment burdens.
- Conducted across seven Swiss clinical sites, the retrospective study analyzed 95 eyes from patients who had previously received anti-VEGF therapy for at least six months before starting DEX treatment, focusing on visual acuity and retinal swelling.
- Results showed a significant reduction in anti-VEGF injections after DEX treatment and improvement in retinal thickness, with BCVA remaining stable, while some patients experienced side effects requiring additional
Purpose: To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.
Methods: A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA), start (FA) and end (FA) of laminar flow, and arterial time (ICGA), respectively.
Article Synopsis
- This study explores how adaptive optics-transscleral flood illumination (AO-TFI) imaging can provide detailed insights into retinal pigment epithelium (RPE) changes in cases of central serous chorioretinopathy (CSCR) compared to standard clinical imaging.
- Researchers analyzed 125 AO-TFI images from both affected and healthy eyes, finding significant changes in RPE contrast and patterns during different stages of CSCR.
- The findings indicate that AO-TFI not only gives a clearer picture of outer retinal abnormalities but also reveals previously undetectable RPE issues, underscoring the need for further research to assess the clinical implications of these findings in understanding CSCR progression.