Publications by authors named "I Manini"
Glioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is mediated, at least in part, by the release of exosomes.
View Article and Find Full Text PDFBackground/objectives: Adolescence is an important period of psychophysical development. In this phase of life people acquire greater self-awareness and adopt behaviors that will later shape their lifestyle in adulthood. This study aimed to assess whether family structure can influence adolescents' eating habits.
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- Acute bronchiolitis is a major cause of lower respiratory infections and hospitalizations in children under one year old, prompting a study at the Teaching Hospital in Siena, Italy.
- A retrospective study analyzed 36,031 pediatric ED visits from September 2018 to April 2023, identifying 383 cases of bronchiolitis, which were more frequent in younger children and associated with higher admission rates based on severity.
- The findings suggest implementing better collaboration between hospital services and community care to ensure timely diagnoses and reduce unnecessary ED visits for mild cases of bronchiolitis.
Background: Influenza B/Yamagata viruses exhibited weak antigenic selection in recent years, reducing their prevalence over time and requiring no update of the vaccine component since 2015. To date, no B/Yamagata viruses have been isolated or sequenced since March 2020.
Methods: The antibody prevalence against the current B/Yamagata vaccine strain in Italy was investigated: For each influenza season from 2012/2013 to 2021/2022, 100 human serum samples were tested by haemagglutination inhibition (HAI) assay against the vaccine strain B/Phuket/3073/2013.
Patients affected by glioma frequently experience epileptic discharges; however, the causes of brain tumor-related epilepsy (BTRE) are still not completely understood. We investigated the mechanisms underlying BTRE by analyzing the effects of exosomes released by U87 glioma cells and by patient-derived glioma cells. Rat hippocampal neurons incubated for 24 hours with these exosomes exhibited increased spontaneous firing, while their resting membrane potential shifted positively by 10-15 mV.
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