Publications by authors named "I Maeda"
The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement in homologous recombination (HR), the impact of its overexpression on HR remains unclear. In this study, we investigated the effect of PLK1 overexpression on HR using bioinformatics and experimental approaches.
View Article and Find Full Text PDFCarotid artery stenting (CAS) has traditionally been performed using the transfemoral approach (TFA). Recently, the transradial approach (TRA) has gained attention for its lower invasiveness and reduced complication risk. This study compares outcomes between two access strategy timeframes, TFA-first and TRA-first, to evaluate how this shift influences outcomes in a real-world setting.
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- Delirium alters cognitive function and may impact the severity of physical symptoms like pain and dyspnea in palliative care patients, but the specific effects of different motor subtypes of delirium are not fully understood.
- A study analyzed patient data from 23 hospices in Japan, focusing on advanced cancer patients who experienced delirium and its motor subtypes at the time of admission and later on.
- Results indicated that patients with hyperactive or mixed delirium had significantly higher odds of experiencing severe pain and dyspnea compared to those without delirium, while hypoactive delirium did not show a similar association.
Recurrence score-predicted value derived from estrogen receptor, tumor-infiltrating lymphocytes, progesterone receptor, and Ki-67 may substitute for the Oncotype DX recurrence score in estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)- breast cancer.
Ann Diagn Pathol
February 2025
Oncotype DX is the only multigene assay supported by the National Comprehensive Cancer Network (USA) with Level 1 evidence for use on node-negative and postmenopausal node-positive patients with estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)-breast cancer to predict the prognosis and to estimate chemotherapy add-on effects. However, the test's high cost prevents its use in most cases. Therefore, we aimed to obtain an alternative recurrence score (RS) prediction formula using the optimal clinicopathological factors.
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- The study investigates the frequency and complications of falls in palliative care units (PCUs) for advanced cancer patients and how these relate to independence and quality of dying.
- Among 1,633 patients observed, 150 (9.2%) experienced falls in the last month of life, primarily due to needing to use the toilet, with serious injuries being very rare.
- The findings suggest that while falls can be common, they are not necessarily harmful and may reflect a patient's independence, indicating that healthcare providers should balance fall prevention with supporting patient autonomy.