Publications by authors named "I Macavei"
Article Synopsis
- Gene duplication, particularly of the porin OmpF, plays a significant role in the evolution of microbial genomes, impacting their interaction with host plants, especially in the case of soft rot disease.
- The OmpF gene duplication was found to be detrimental to the virulence of the pathogen, thus contradicting the typical idea that duplicated genes always confer an advantage.
- The regulation of the EnvZ-OmpR system, which responds to pH changes, is complicated by plant defenses that produce phenolic acids, ultimately suppressing the expression of potentially harmful genes during infection.
Article Synopsis
- The study investigates how different levels of expression of virulence proteins in a bacterial pathogen relate to the severity of staphylococcal pneumonia in patients, highlighting the challenges of measuring these levels consistently.
- Using a targeted proteomics technique, the researchers analyzed 136 isolates from French patients and identified specific virulence factors that predict severe symptoms like leukopenia and hemoptysis, as well as patient survival.
- Notably, the expression of the Panton-Valentine leucocidin was found to be a significant predictor of mortality, suggesting that targeted proteomics could be valuable for understanding infection dynamics in other bacterial diseases.
348 spleens surgically removed have been examined microscopically and classified into 3 groups: (I) 154 emergency splenectomies (86 traumatic ruptures, 44 enlarged supramesocolic exeresis, 44 cirrhosis), (II) 143 therapeutic splenectomies (135 cases of hypersplenism among which 10 apparently primitive, 7 myeloproliferative syndromes, 1 hairy cell leukemia), and (III) 51 diagnostic splenectomies (7 non specific inflammations, 2 tuberculosis, 1 mycosis, 6 echinococcosis, 12 leukemias, 9 non-Hodgkin's lymphomas, 13 Hodgkin's lymphomas, 1 primary splenic hemangioma). The study of the first group material, obtained especially of traumatic rupture, has been very valuable to follow the spleen microscopic structure in normal humans of different age. The latter two group cases have raised interesting problems of microscopic diagnosis, permitting at the same time a better understanding of the pathology of this organ.
View Article and Find Full Text PDFBone marrow biopsy (BMB). III. Bone marrow biopsy in Hodgkin's disease (HD).
Morphol Embryol (Bucur)
March 1991
Bone marrow biopsies have been investigated in 330 cases of Hodgkin's disease totalising 298 patients, out of which 32 with repeated biopsies. Positive biopsies with typical lesions were found in 32% of patients, the majority in stages III and IV (88.6%), rarely in stage I or II (11.
View Article and Find Full Text PDFBone marrow biopsy (BMB). II. Bone marrow biopsy in myeloproliferative disorders.
Morphol Embryol (Bucur)
November 1989
The myeloproliferative disorders (MPD) are a domain in which the bone marrow biopsy (BMB) greatly proved its utility. We have studied the histology of the bone marrow (BM) in all the four entities of MPD: chronic myeloid leukemia (CML) with its subtype, chronic megakaryocytic granulocytic myelosis (CMGM), polycythemia vera (PV), hemorrhagic thrombocythemia (HT) and myeloid metaplasia with myelofibrosis (MMM). The work presents in short some of the clinical and hematologic characters of MPD with special stress upon the histologic modifications of BM, either specific or common to all MPD entities, underlying also the criteria for differential diagnosis.
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