Publications by authors named "I MacLeod"
Background: Anecdotally, upper truncal obesity and large breasts have often been associated with inferior outcomes from non-operative management of diaphyseal humerus fractures. However, this assertion is without basis in the literature.
Aims: To produce radiographic measurements of chest wall soft tissue thickness (STT) and determine association with non-union in diaphyseal humerus fractures.
Article Synopsis
- Genotype imputation helps in obtaining sequence genotypes for analyses like genome-wide association studies (GWAS), but assessing imputation accuracy is crucial to avoid false positives.
- The study compared three imputation programs—Beagle 5.2, Minimac4, and IMPUTE5—and found that high-density genotypes yield better accuracy than low-density, with notable differences in how each software estimates imputation performance.
- The findings highlight the need for customized Rsq thresholds when filtering data and indicate that INDEL variants tend to have lower accuracy than SNPs; also, the accuracy of X chromosome imputation varies significantly between different regions.
Background: Mitochondrial genomes differ from the nuclear genome and in humans it is known that mitochondrial variants contribute to genetic disorders. Prior to genomics, some livestock studies assessed the role of the mitochondrial genome but these were limited and inconclusive. Modern genome sequencing provides an opportunity to re-evaluate the potential impact of mitochondrial variation on livestock traits.
View Article and Find Full Text PDFBackground: Mastitis is a disease that incurs significant costs in the dairy industry. A promising approach to mitigate its negative effects is to genetically improve the resistance of dairy cattle to mastitis. A meta-analysis of genome-wide association studies (GWAS) across multiple breeds for clinical mastitis (CM) and its indicator trait, somatic cell score (SCS), is a powerful method to identify functional genetic variants that impact mastitis resistance.
View Article and Find Full Text PDFWidespread genotyping has enabled the identification of putative recessive mutations that affect fertility through early embryonic fetal loss, or that compromise neonate or calf viability. The use of artificial insemination in the global dairy population can rapidly spread these harmful mutations, and testing for multiple mutations can become relatively expensive if not all tests are available on the same SNP panel. However, it is possible to provide heifer and cow predicted carrier status to farmers at no additional cost if the animals are genotyped with a standard SNP panel.
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