Lung Cancer Screening Before and After a Multifaceted Electronic Health Record Intervention: A Nonrandomized Controlled Trial.

Importance: Lung cancer is the deadliest cancer in the US. Early-stage lung cancer detection with lung cancer screening (LCS) through low-dose computed tomography (LDCT) improves outcomes.

Objective: To assess the association of a multifaceted clinical decision support intervention with rates of identification and completion of recommended LCS-related services.

Studies of Protein Binding to Biomimetic Membranes Using a Group of Uniform Materials Based on Organic Salts Derived From 8-Anilino-1-naphthalenesulfonic Acid.

Tuning the 8-anilino-1-naphthalenesulfonic acid (ANS) structure usually requires harsh conditions and long reaction times, which can result in low yields. Herein, ANS was modified to form an ANS group of uniform materials based on organic salts (GUMBOS), prepared with simple metathesis reactions and distinct cations, namely tetrabutylammonium (N), tetrahexylammonium (N), and tetrabutylphosphonium (P). These ANS-based GUMBOS were investigated as fluorescent probes for membrane binding studies with four proteins having distinct physicochemical properties.

Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential.

Antimicrobial resistance is a silent pandemic considered a public health concern worldwide. Strategic therapies are needed to replace antibacterials that are now ineffective. One approach entails the use of well-known antibacterials along with adjuvants that possess non-antibiotic properties but can extend the lifespan and enhance the effectiveness of the treatment, while also improving the suppression of resistance.

Microbial Primer: Transposon directed insertion site sequencing (TraDIS): A high throughput method for linking genotype to phenotype.

Genetic screens are a key tool for linking phenotype and genotype. Transposon mutagenesis was one of the first genetic methodologies to associate genetic loci with phenotypes. The advent of next-generation sequencing transformed the use of this technique allowing rapid interrogation of whole genomes for genes that correlate with phenotype.

Influence of humidity on accuracy of QCM - IR780-based GUMBOS sensor arrays.

Herein, hydrophobic coating materials are reported for QCM detection of VOCs under dry and humid conditions. In this study, IR780-based GUMBOS ([IR780][OTf] and [IR780][NTf2]) were synthesized using an ion exchange reaction and the anions trifluoromethanesulfonimide ([OTf]) and bisperfluoromethanesulfonimide ([NTf2]). The parent iodide salts and GUMBOS ([IR780][I]), [IR780][OTf], and [IR780][NTf2]) were characterized using several analytical techniques.