Publications by authors named "I M Wakelkamp"
Article Synopsis
- This study investigates preoperative workups for indeterminate thyroid nodules (ITN) to differentiate between malignant and benign cases, focusing on molecular diagnostics (MD) and [F]FDG-PET/CT scans.
- Findings show that MD had a higher negative predictive value (91%) than [F]FDG-PET/CT (95%), but the combination of both tests improved overall sensitivity and specificity.
- The analysis indicates that MD is particularly effective with oncocytic ITN, demonstrating a low benign call rate for [F]FDG-PET/CT and suggesting that the choice of diagnostic method may differ across regions.
Article Synopsis
- The text talks about treating prolactinomas, which are tumors that affect hormones, using either medicine or surgery.
- Medicines called dopamine agonists (DAs) work for many people, but some have bad side effects and might need to keep taking them for a long time.
- The study is checking if having surgery early on is better than using DAs for people with small tumors in terms of health and chances of getting better. *
Agranulocytosis is a rare and serious adverse effect of antithyroid drugs, with unknown etiology. The present study aimed to uncover genetic susceptibility and underlying mechanisms of antithyroid drug-induced agranulocytosis (ATDAC). We studied two independent families with familial Graves' disease, of which several members developed ATDAC.
View Article and Find Full Text PDFInsulin can be measured by immunochemical methods using polyclonal or monoclonal antibodies. Monoclonal antibodies are specific in the detection of pure human insulin, and may show little to no cross reactivity with pro-insulin or recombinant insulin. Polyclonal antibodies, however, do show such cross reactivity.
View Article and Find Full Text PDF[Agranulocytosis/granulocytopenia after long-term use of thiamazole].
Ned Tijdschr Geneeskd
July 2011
Agranulocytosis/granulocytopenia is a rare side effect of thyreostatics. Earlier publications state that for thiamazole this side effect occurs during the first few months of treatment. In two patients this thiamazole-induced agranulocytosis/granulocytopenia only occurred after years of treatment.
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