Publications by authors named "I M Vural"
Article Synopsis
- This study investigates the antinociceptive (pain-relieving) effects of taraxasterol, a compound from dandelion, and its possible mechanisms of action by looking at its impact on various pain tests in mice.
- The results showed that taraxasterol significantly increased pain relief in certain tests and that its effects were influenced by the GABAergic and opioidergic systems, as well as K channels.
- The findings suggest that taraxasterol could be a promising herbal remedy for pain management, highlighting its potential use in future treatments.
Article Synopsis
- Cancer diagnosis is on the rise globally, and access to cancer drugs is a key health policy issue in Türkiye; researchers used drug sales data to evaluate this access.
- The study analyzed sales data from IQVIA, adjusting for factors like population growth, cancer rates, and Euro exchange rates, revealing varying drug consumption trends based on cancer type.
- Findings indicated that pricing strategies, influenced by exchange rates and population factors, are barriers to accessing oncology medicines, prompting a need for policy review to improve access.
Background: The endocannabinoid system plays important roles in various systems, including the genitourinary system; however, its mechanism of action is not fully understood.
Objectives: This study aimed to investigate the direct relaxant effects of anandamide and its possible mechanisms in isolated rat bladder and vas deferens tissues.
Methods: Twenty-one adult male Wistar albino rats were used.
Interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue.
Naunyn Schmiedebergs Arch Pharmacol
June 2024
The endocannabinoid system and prostaglandins are important modulators in the genitourinary system. This study aimed to investigate the possible interactions between the endocannabinoid system and the cyclooxygenase (COX) pathway on rat vas deferens. For this purpose, the concentration responses of the endocannabinoid anandamide, prostaglandin F analog latanoprost, and prostaglandin E analog misoprostol on the electrical field stimulation (EFS)-induced contractile responses were obtained.
View Article and Find Full Text PDFProstate cancer is a global disease that negatively affects the quality of life. Although various strategies against prostate cancer have been developed, only a few achieved tumor-specific targeting. Therefore, a special emphasis has been placed on the treatment of cancer using nano-carrier-encapsulated chemotherapeutic agents conjugated with tumor-homing peptides.
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