[Antiamnesic action of nomifensine].

Nomifensine efficiency in the improvement of memory trace restoration impaired by spontaneous forgetting or amnesic influence was demonstrated in experiments on BALB/c mice by using the passive avoidance technique. Doses of 10-20 mg/kg proved to be the most efficient. The presented results suggest that the antiamnesic effect of nomifensine is due to the activation of dopaminergic and noradrenergic systems.

[Bupropion activation of memory trace retrieval in amnesia and forgetting].

The effect of a new antidepressant bupropion on the processes of retrieval of the conditioned response of passive avoidance in mice under amnesia of different genesis and spontaneous forgetting was studied. The drug was shown to exert the antiamnesic effect and to facilitate retrieval of amnesia-affected or forgotten memory trace. The maximal effect of bupropion was observed at the dosage of 30 mg/kg.

[Reproduction of a memory trace in amnesia and forgetting following alteration in the activity of pre- and postsynaptic dopamine receptors].

The paper deals with analysis of the action of enantiomers 3-PPP on memory trace reproduction disturbed by amnestic effects and spontaneous forgetting in mice. A considerable antiamnestic effect is shown of (+)3-PPP and (-)3-PPP in 10 mg/kg doze changing the activity of postsynaptic dopamine receptors. The influence of drugs in 2 mg/kg doze changing the activity of presynaptic receptors consisted in recovery of conditioned habit only in situation of a weak amnestic effect and at forgetting, when the level of reproduction was like a weak amnesia.

[Facilitation of memory trace retrieval by the action of amfonelic acid].

Amfonelic acid exerting the central dopaminergic effect was studied on mice by the passive avoidance conditioned response method under amnesia induced by leaving the animals in a dark chamber following electrocutaneous stimulation and different terms of natural forgetting. Amfonelic acid was shown to prevent the amnesic effect, to improve retrieval of the conditioned response decreased as a result of amnesia or prolonged forgetting.

[Effect of benzodiazepine receptor blockade on memory processes in the mouse].

The results of study testify to a stimulating effect of benzodiazepine receptors blocators RO15-1788 and RO15-3505 on reproduction of conditioned reaction of passive avoidance in mice disturbed as a result of various procedures-"psychogenic" and cycloheximide amnesia, extinction and forgetting. A considerable antiamnesic effect of the drugs on cycloheximide amnesia models is noted, in comparison with the "psychogenic" one. RO15-3505 is more effective in the processes of extraction of memory traces under amnesia.