[Investigation of chromosomal anomalies by fluorescence in-situ hybridization (fish) in Armenia].

Prenatal and postnatal molecular-cytogenetic investigations of 75 patients have been performed. 3-stage international standard of patients' examination was used, including general clinical examination, investigation by the methods of conventional cytogenetics and molecular-cytogenetic fluorescence in-situ hybridization (FISH) analysis. On the basis of cytogenetic investigation we can conclude that in 25% of cases of complex chromosomal anomalies the cytogenetic diagnosis, obtained by means of conventional karyotyping, needed further specification.

[Diagnosis of mosaic forms of karyotype anomalies in clinical cytogenetic research].

Mosaicism cases have been statistically analyzed with the aim to develop a general scheme of the cytogenetic study. Using the Bernoulli formula it is shown that when P = 0.95 and proportion of clones is 10:90% and more 29 cells should be initially analyzed.