Publications by authors named "I M Rea"
Porous silicon is one of the most explored nanostructured materials in various biomedical applications owing to its remarkable properties. However, its inherent chemical instability mandates a robust surface modification procedure, and proper surface bioengineering is essential to ensure its effectiveness in the biomedical field. In this study, we introduce a one-pot functionalization strategy that simultaneously stabilizes porous silicon nanoparticles and decorates their surface with carbohydrates through hydrosilylation chemistry, combining mild temperatures and a Lewis acid catalyst.
View Article and Find Full Text PDFMicroRNAs (miRNAs) are small non-coding RNAs (18-22 nucleotides) that regulate gene expression and are associated with various diseases, including Laryngeal Cancer (LCa), which has a high mortality rate due to late diagnosis. Traditional methods for miRNA detection present several drawbacks (time-consuming steps, high cost and high false positive rate). Early-stage diagnosis and selective detection of miRNAs remain challenging.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on metastasis-initiating cells in colorectal cancer (CRC) and explores the relationship between TGF-β signaling and L1CAM, aiming to combat cancer progression and resistance.
- Researchers developed a hybrid nanosystem using gold nanoparticles covered with porous biosilica and modified with L1CAM antibodies, which targets tumor-initiating cells and delivers a TGF-β inhibitor to reduce metastasis.
- Results showed that the nanosystem effectively decreases tumor growth in CRC models, demonstrating its potential for targeted therapy and imaging, paving the way for personalized treatment strategies.
Herein, we evaluated the interaction of the tetracationic porphyrin HTCPPSpm4 with three distinct DNA G-quadruplex (G4) models, i.e., the tetramolecular G4 d(TGGGGT) (Q), the 5'-5' stacked G4-dimer [d(CGGAGGT)] (Q), and a mixture of 5'-5' stacked G-wires [d(5'-CGGT-3'-3'-GGC-5')] (Q).
View Article and Find Full Text PDFArticle Synopsis
- The study explores how nanostructures in organisms, like diatoms, can manipulate light for communication and photosynthesis.
- Diatoms, tiny microalgae with silica cell walls, have evolved unique structures to efficiently handle light, enhancing their photosynthetic capabilities.
- Using various imaging and simulation techniques, the research shows that these structures help optimize light for photosynthesis while protecting against harmful UV radiation.