Publications by authors named "I M Phillips"
Background: The Scottish Inflammatory Prognostic Score (SIPS), combining albumin (≥/<35 g/L) and neutrophil count (≤/>7.5 × 10/L), has been identified as a prognostic biomarker for patients with non-small cell lung cancer (NSCLC) undergoing treatment with pembrolizumab monotherapy. We sought to validate this biomarker of systemic inflammation in an external cohort.
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- The global population is aging, and cancer rates are increasing, leading to more older adults living with cancer and requiring specialized care.
- Recent advancements in oncology, such as earlier diagnosis and diverse treatment options, highlight the importance of preparing health services to effectively care for older cancer patients who often have complex needs.
- This paper reviews the significant progress made in the UK in providing comprehensive geriatric assessments and new clinical services for older cancer patients, aiming to share these improvements with other healthcare systems.
Article Synopsis
- Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) resembles viral responses, affecting tumor cells and their microenvironment.
- A study on 46 primary tumors revealed that high repeat RNA levels correlate with changes in cell identity in both PDAC cells and cancer-associated fibroblasts (CAFs).
- The distinct immune signaling pathways in PDAC and CAFs, particularly involving interferon regulatory factor 3 (IRF3), highlight how these viral-like responses impact cellular flexibility and interactions within the tumor environment.
A traffic light approach for treatment and supportive care stratification in lung cancer.
Curr Opin Support Palliat Care
September 2024
Purpose Of Review: Comprehensive supportive care interventions for patients with lung cancer are being investigated in a range of ways, including: early palliative care, prehabilitation and rehabilitation. We review recent literature on supportive care and propose a traffic light system to individualise comprehensive supportive care. Green for those very likely to receive anti-cancer treatment, red for those very unlikely to receive anti-cancer treatment and orange where the chance of accessing treatment is uncertain.
View Article and Find Full Text PDFBilateral adrenal hyperplasia associated with primary lung cancer may arise from either an adrenocorticotropic hormone (ACTH)-dependent paraneoplastic syndrome or metastatic hyperplasia. Ectopic Cushing's syndrome manifests as a paraneoplastic syndrome characterized by the secretion of ACTH from malignant cells. This secretion can in turn overstimulate the adrenal cortex, resulting in adrenal cortical hyperplasia followed by hypercortisolism.
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