Visual outcomes and complications after phacoemulsification and small incision manual cataract surgery in two eye hospitals.

Purpose: To evaluate and compare the visual outcomes and complications of cataract surgery in two referral eye hospitals in southern Nigeria.

Methods: Case records of patients who underwent elective cataract surgery at two referral eye hospitals from February 2017-2022 were collected retrospectively. Demographics, preoperative visual acuity (VA), anterior and posterior segment details, intraoperative and postoperative complications, VA at day 1, 1 week, and 1 month postoperatively were analyzed.

Novel pyrrolidine-aminophenyl-1,4-naphthoquinones: structure-related mechanisms of leukemia cell death.

Novel derivatives of aminophenyl-1,4-naphthoquinones, in which a pyrrolidine group was added to the naphthoquinone ring, were synthesized and investigated for the mechanisms of leukemic cell killing. The novel compounds, TW-85 and TW-96, differ in the functional (methyl or hydroxyl) group at the para-position of the aminophenyl moiety. TW-85 and TW-96 were found to induce concentration- and time-dependent apoptotic and/or necrotic cell death in human U937 promonocytic leukemia cells but only TW-96 could also kill K562 chronic myeloid leukemia cells and CCRF-CEM lymphoblastic leukemia cells.

Targeting Necrosis: Elastase-like Protease Inhibitors Curtail Necrotic Cell Death Both and in Three Disease Models.

Necrosis is the main mode of cell death, which leads to multiple clinical conditions affecting hundreds of millions of people worldwide. Its molecular mechanisms are poorly understood, hampering therapeutics development. Here, we identify key proteolytic activities essential for necrosis using various biochemical approaches, enzymatic assays, medicinal chemistry, and siRNA library screening.

COVID-19 relief food distribution: impact and lessons for Uganda.

The COVID-19 pandemic continues to cause uncertainty to Uganda's food security among underprivileged households. The Corona virus Response Team inaugurated a relief food distribution campaign, ensuing from the countrywide COVID-19 lockdown to counter the rising food insecurities in many urban and rural poor households. However, the relief response campaign has received a lot of critics from both rural and urban communities who were planned as the beneficiaries.