Publications by authors named "I M Lubin"
Article Synopsis
- Sorafenib and lenvatinib are drugs used to treat liver cancer (HCC), but this study examines how hepatitis B virus (HBV) infection impacts their effectiveness in liver cancer cells (HepG2).
- In HBV-infected HepG2 cells, there were notable changes in cell cycle gene expressions, leading to increased cell proliferation and resistance to both drugs, despite them decreasing cell viability in uninfected cells.
- The study found that while both drugs can lower certain signaling proteins in the cells, HBV infection specifically makes HepG2 cells less responsive, showing different resistance mechanisms for each drug.
Article Synopsis
- Value-based laboratory medicine focuses on improving patient outcomes by enhancing the clinical utility of diagnostic tests while optimizing resources and reducing costs.
- Key elements include the organization of diagnostics, translating lab data into meaningful clinical information, and addressing ethical considerations such as patient empowerment and big data analysis.
- The paper summarizes insights from the EFLM Strategic Conference and highlights the importance of education, technological advancements, and future regulations in shaping the profession.
(MF) and (SS) are the most common types of primary cutaneous T-cell lymphoma (CTCL). Proliferating cell nuclear antigen (PCNA) is expressed on the cell surface of cancer cells (csPCNA), but not on normal cells. It functions as an immune checkpoint ligand by interacting with natural killer (NK) cells through the NK inhibitory receptor NKp44, leading to the inhibition of NK cytotoxicity.
View Article and Find Full Text PDFClinical practice guidelines (CPGs) support individual and population health by translating new, evidence-based knowledge into recommendations for health practice. CPGs can be provided as computable, machine-readable guidelines that support the translation of recommendations into shareable, interoperable clinical decision support and other digital tools (eg, quality measures, case reports, care plans). Interdisciplinary collaboration among guideline developers and health information technology experts can facilitate the translation of written guidelines into computable ones.
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