Publications by authors named "I M L Ahout"
Children with Medical Complexity (CMC) often require 24/7 expert care, which may impede discharge from hospital to home (H2H) resulting in prolonged admission. Limited research exists on pediatric patients with delayed discharges and the underlying reasons for such extended admissions. Therefore, our objectives were to (1) describe the demographics, clinical characteristics, and course of CMC who are in their H2H transition and (2) identify the reasons for postponement of H2H discharge.
View Article and Find Full Text PDFBackground: Children with life-threatening and life-limiting conditions can experience high levels of suffering due to multiple distressing symptoms that result in poor quality of life and increase risk of long-term distress in their family members. High quality symptom treatment is needed for all these children and their families, even more so at the end-of-life. In this paper, we provide evidence-based recommendations for symptom treatment in paediatric palliative patients to optimize care.
View Article and Find Full Text PDFArticle Synopsis
- RSV (Respiratory syncytial virus) is a leading cause of severe respiratory infections in infants, highlighting the need for better understanding of maternal antibodies and their role in protection.
- Antibody levels alone do not effectively correlate with protection against RSV; instead, the ability of antibodies to activate natural killer (NK) cells may be more critical.
- The study suggests that the quality of antibodies, particularly their Fc-glycosylation status, affects NK cell activation and may play a significant role in protecting against severe RSV disease, indicating potential avenues for vaccine improvement.
Background: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection.
View Article and Find Full Text PDFBackground: The influenza H1N1 pandemic of 2009-2010, provided a unique opportunity to assess the course of disease, as well as the analysis of risk factors for severe disease in hospitalized children (< 18 years).
Methods: Retrospective national chart study on hospitalized children with H1N1 infection during the 2009-2010 pH1N1 outbreak.
Results: Nine hundred forty patients (56% boys), median age 3.