[The expert evaluation of enhancement of organization of functioning of territorial polyclinic].

The planning of optimizing activities of out-patient service is appropriate to carry out examination of opinions of administrators of ambulatory medical organizations. The expertise of 70 head physicians and their deputies of treatment activities of ambulatory medical organizations of Novosibirsk determined directions of optimization of functioning of territorial polyclinic. The applied activities resulted in decreasing of indicators of period of visiting, and level of social deadaptation of patients.

[The opinions of district physicians-therapists concerning expedience of distant counseling of patients at the ambulatory level].

The sociological survey of 91 district physician-therapists was carried out to evaluate degree of implementation by patients of prescribed treatment. At the same time, most of the respondents assume that untimely decision of issues appeared in patients during treatment process decrease effectiveness of prescribed treatment. Besides, these issues very often can be resolved using Internet.

[The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine)].

Synthesis is described and acute toxicity and antimalaria action is studied in new derivatives of quinoline and benzo(g)quinoline containing a 4-(4-alkylpiperazinyl-1)phenylamine substitute. Only the derivatives of benzo(g)quinoline were found to have a high antimalaria effect and to have advantages over the standard agent chloroquine on their tolerance and protective action. One of the compounds, 4-[4-(4-ethylpiperazinyl-1)phenylamino] benzo(g)quinoline, named QUINOPRAZINE, showed some action against Plasmodium berghei chloroquine--resistant infection (isolate LN-K65).

[The modelling of the multiple drug resistance of the malarial parasites. 1. The combined resistance of Plasmodium berghei to chloroquine and fansidar].

Using a recurrent technique, P. berghei isolate resistant to chloroquine-fansidar combination is formed in golden hamsters. The isolate resistant to chloroquine-fansidar combination was 4 times less sensitive to chloroquine, 2 times less sensitive to fansidar and its combinations, 2 times less sensitive to sulfadoxine, 31 times less sensitive to pyrimethamine, as compared to the baseline isolate LNK65 P.