[Comparative evaluation of the clinical course and dynamics of the morphological changes in chronic glomerulonephritis].

The results of a simultaneous study of a clinical and morphological course of chronic glomerulonephritis (CGN) in 30 patients after repeated morphological investigation of the renal tissue showed that a prevailing tendency in this disease was the progression of morphological changes which could be noted in a stable clinical picture and even in clinical improvement. The detection of tubulointerstitial changes in the first nephrobiopsy was an unfavorable prognostic factor. Of the greatest importance for indirect assessment of a morphological course of CGN were changes in creatinine clearance, effective renal plasma flow and arterial pressure.

[Tubulointerstitial component of chronic glomerulonephritis. Clinico-morphological comparisons].

A total of 179 patients with chronic glomerulonephritis were examined for the development of the tubulo-interstitial component (TIC) of the disease. It was established that the rate of the development and intensity of the TIC are linked with different morphological variants of GN and increase successively in mesangiomembranous, membranous, mesangioproliferative, mesangiocapillary (and lobular) GN, reaching a maximum in diffuse fibroplastic GN. In patients with no TIC, the hematuric and latent forms of CGN were mostly encountered.