Publications by authors named "I M Johansen"
Objective: Accelerated ageing indexed by telomere attrition is suggested in schizophrenia spectrum- (SCZ) and bipolar disorders (BD). While inflammation may promote telomere shortening, few studies have investigated the association between telomere length (TL) and markers of immune activation and inflammation in severe mental disorders.
Methods: Leucocyte TL defined as telomere template/amount of single-copy gene template (T/S ratio), was determined in participants with SCZ ( = 301) or BD ( = 211) and a healthy control group (HC, = 378).
Background And Aims: The emergence of biologic therapy has coincided with a decline in surgery rates for Crohn's disease (CD). This study aims to describe the disease course, including intra-abdominal surgery rates, biologic therapy use, and variables associated with biologic therapy initiation in a cohort of newly diagnosed CD patients.
Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study.
The potato family includes a highly diverse cultivar repertoire and has a high potential for nutritional yield improvement and refinement but must in line with other crops be adapted to biotic and abiotic stresses, for example, accelerated by climate change and environmental demands. The combination of pluripotency, high ploidy, and relative ease of protoplast isolation, transformation, and regeneration together with clonal propagation through tubers makes potato highly suitable for precise genetic engineering. Most potato varieties are tetraploid having a very high prevalence of length polymorphisms and small nucleotide polymorphisms between alleles, often complicating CRISPR-Cas editing designs and strategies.
View Article and Find Full Text PDFObjective: To investigate the use of non-barrier contraceptives among women with HIV (WWH) compared to women from the general population (WGP) in Denmark.
Design: Nationwide population-based matched cohort study.
Methods: We included WWH aged 16-50, treated at an HIV specialized clinic, and included in The Danish HIV Cohort Study between 1995-2021 and an age-matched comparison cohort of WGP.
Article Synopsis
- The study examined the relationship between bipolar disorders and the risk of HIV infection, as well as the risk of bipolar disorders in people with HIV (PWH) and their siblings.
- It used data from a large Danish population-based study, analyzing information from over 5,000 PWH and more than 53,000 matched individuals from the general population.
- Results showed that bipolar disorder increases the risk of HIV infection significantly, especially among injection drug users, and that PWH have a notably higher risk of developing bipolar disorder, particularly in the first two years after diagnosis.