[The characteristics of the morphofunctional restructuring of the aortic endothelium in food-related atherosclerosis and hyperadrenalinemia].

Morphofunctional reorganization was studied of endothelium during the stage of formation of alimentary atherosclerosis and in experimental hyperadrenalinemia using transmission electronic microscopy and histochemistry together with silver nitrate impregnation of aortal endothelial monolayer. Certain morphofunctional equivalents have been established for the vascular wall exposure to the above factors, indicative of their unequalability and possibility of potentiation under combination. In both cases, an interrelationship similar in character has been shown between intensity of the endothelial reciprocal response and its regional morphofunctional features.

[Role of hypercholesterolemia in the pathogenesis of atherosclerosis].

The pathogenic role of hypercholesterolemia in the development of atherosclerosis was determined by investigation of the vessel's wall structural and functional peculiarities in rabbits, which were kept on atherogenic diet. It was evident, that even short duration of hypercholesterolemia led to significant disturbances of vascular reactivity, which manifested mainly in the inhibition of endothelial vasomotor activity against a background of the initial increase of smooth muscle sensitivity to contracting influences. These changes were almost the same in quality and magnitude in all the investigated sections of the vascular system including venous.

[Character and mechanisms of changes in vascular wall reactivity in prolonged hypercholesterolemia].

Changes in the structure and functional properties of the vascular wall after 8 months of alimentary hypercholesterolemia (HCE) were studied. The experiments were conducted on the circular bands of the arch of the aorta in rabbits. Sharp inhibition of the reactivity of the vascular bands was established, which was associated first of all with thickening of the intima due to the development of fibro-atheromatous changes in it.

[Efficacy of vascular wall protection from atherosclerotic damage using various calcium antagonists].

The authors studied the effect of various calcium antagonists--verapamil (VP) and Mg2+ (MgCl2) on the character of affection of the vascular wall ulcer conditions of prolonged hypercholesterolemia (HCE). The blood cholesterol (CS) content increased by the end of the 8th month of HCE to eight-fold the value in intact animals. The specific atherosclerotic changes in this case occupied approximately 80% of the area of the thoracic aorta whose functional properties changed essentially.