Publications by authors named "I M Hirfanoglu"
Background: Despite recommendations to limit the use of vancomycin for known resistant infections, it remains one of the most commonly prescribed antibiotics in neonatal intensive care units (NICUs). One of the most effective approaches to reducing unnecessary antibiotic exposure is through the implementation of antibiotic stewardship programmes (ASPs).
Aim: The objective of this study was to evaluate the effectiveness of ASPs in reducing the use of vancomycin in neonates hospitalized in our NICU.
MiRNA 148a, which is associated with various biological processes such as immunity and cell differentiation, is one of the most abundant miRNAs in breast milk. This study aimed to determine the amount of miRNA 148a in different infant formulas, which are used for infants who cannot receive breast milk. The study analyzed 20 formulas, including stage one infant formulas (0-6 months of age), stage two follow-up formulas (6-12 months of age), stage three toddler formulas (above 12 months of age), and premature ones, analyzing miRNA 148a expression and qPCR miRNA gene expression, with significance set at p < 0.
View Article and Find Full Text PDFHuman breast milk is a complex biological fluid containing multifaceted biological compounds that boost immune and metabolic system development that support the short- and long-term health of newborns. Recent literature suggests that human breast milk is a substantial source of nutrients, bioactive molecules, and exosomes. This review examines the factors influencing exosomes noted in human milk and the impacts of exosomes on infant health.
View Article and Find Full Text PDFArticle Synopsis
- This study looked at how doctors treat babies with a serious condition called long-gap esophageal atresia (LGEA) using special methods.
- They checked the medical records of 10 patients and found that different surgical techniques were used, like the Foker and Gazi methods, to help the babies eat normally.
- It was important for these surgeries to be done by skilled surgeons in special hospitals to get the best results for the babies.
Article Synopsis
- - The study investigates the incidence of hypoxic ischemic encephalopathy (HIE) in infants ≥36 weeks gestational age in Turkey, finding an incidence rate of 2.13 per 1000 live births, with varying severity levels among those affected.
- - Among infants with HIE, therapeutic hypothermia (TH) was notably administered to 34.5% of those with mild HIE, while factors like gestational age affected mortality rates, especially in those born at 34-35 weeks.
- - Despite an unchanged incidence of HIE, the study revealed a decreased mortality rate and no significant impact of TH timing on MRI findings or mortality.