Publications by authors named "I M El-Naggar"
Background And Objectives: Pediatric patients with acute disseminated encephalomyelitis (ADEM) are at risk of impaired brain growth, with long-term neuropsychiatric consequences. We previously reported transient expansions of cerebral ventricle volume (VV) in experimental autoimmune encephalomyelitis, which subsequently normalized. In this study, we investigated changes in VV in ADEM in relation to other brain structures and clinical outcomes.
View Article and Find Full Text PDFLong-term follow-up MR imaging in children with transverse myelitis.
Mult Scler Relat Disord
December 2024
Article Synopsis
- The study investigates how lesions in children with transverse myelitis (TM) resolve over time, focusing on different related diseases: MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and double seronegative TM.
- A total of 78 children from various medical centers were assessed, and a grading system was used to measure the resolution of lesions over time.
- Results showed that MOGAD had the fastest and most complete resolution of lesions, followed by double seronegative TM, MS, and NMOSD, with none of the NMOSD patients achieving complete resolution during the observation period.
CSF-profile and hypocretin levels in children with narcolepsy type 1 and 2.
Eur J Paediatr Neurol
November 2024
Background: Narcolepsy is a rare neurological disease caused by dysfunction of hypocretin-producing neurons. Hypocretin concentrations in the cerebrospinal fluid (CSF) of less than 110 pg/ml are considered pathological in adults.
Objectives: To compare hypocretin levels of children with narcolepsy type 1, type 2 and disease control groups, in addition to a detailed CSF analysis, clinical and polysomnographic parameters.
Introduction: Neuroimmunological diseases such as autoimmune encephalitis (AE) or acquired demyelinating syndromes (ADS), can present with neurological symptoms and imaging features that are indistinguishable from mitochondrial diseases (MD) in particular at initial presentation.
Methods: Retrospective analysis of the clinical, laboratory and neuroimaging features of five patients who presented with signs of a neuroimmunological disease but all had pathological pathogenic variants in genes related to mitochondrial energy metabolism.
Results: Four patients presented with an acute neurological episode reminiscent of a possible AE and one patient with a suspected ADS at initial presentation.
MR imaging in children with transverse myelitis and acquired demyelinating syndromes.
Mult Scler Relat Disord
November 2022
Article Synopsis
- Transverse myelitis (TM) can occur alone or with other demyelinating syndromes like multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD).
- The study aimed to analyze clinical and MRI features of children with autoimmune demyelinating syndromes (ADS) presenting with TM, looking specifically at their antibody status.
- Findings showed distinct MRI patterns: children with MOGAD had more grey matter involvement and higher leptomeningeal enhancement, while those with MS had a mix of short and long lesions in both grey and white matter, and double seronegative kids primarily showed long lesions.