[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 3. Genetic characteristics of adaptive norm].

Was undertaken the effort to define the limits of the adaptive norms and of high risk groups in regard to the work connected with fissile materials (FM), radioactive materials (RM) and ionizing radiation sources (IRS). In view of the aforementioned goal it was made a comparative evaluation of the individual radiosensitivity measurements and anthropometric indicators in the cohort formed from VNIIEF personnel, which was exposed to a constant occupational gamma-neutron irradiation, as well as the non-irradiated cohort. There were analyzed the dispersion dependencies on height, on chest and on head circumference and heterozygosis by 9 loci.

[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in the Russian Federal Nuclear Center (Sarov). Report 2. Genetic and non-genetic risk factors of morbidity].

Below is given a comparative evaluation of the genetic and the epidemiological examination of the cohort comprised by VNIIEF personnel subjected chronically to gamma-neutron ionizing radiation (74 persons), as well as nonirradiated cohort (74 persons). There are obtained data on the influence of the integral genotype structure on the health of an individual in case of occupational irradiation. The epidemiological analysis revealed statistically meaningful differences between the main and the control cohorts in the following five cases: acute respiratory diseases, diseases of upper respiratory tract, brain vessel malfunctions; illnesses connected with vision organs and cardio-vascular system and traumas.

[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 1. Genome structural damage rate and radiosensitivity].

A comparative evaluation of the cytological and dosimetric examination of the cohort comprised by VNIEF personnel subjected chronically to gamma-neutron ionizing radiation, as well as non-irradiated cohort is given. The obtained data on the influence of the occupational and on X-ray irradiation, age and smoking on the rate of structural genome damage, as well as the activity of the human repair system activity are presented. The influence of the individual heterozygosis by 9 polymorphous loci: Hp, Tf, Gc; 6-PGD, EsD, ACP, PGM1, microsatellite lici SCF1PO and F13AO1 is shown.

[The effects of chronic radiation exposure on the frequency of mutations at minisatellite DNA loci in residents of the Techa Riverside Villages].

The frequency of mutations at eight minisatellite DNA loci (B6.7, CEB1, CEB15, CEB25, CEB 36, MS1, MS31 and MS32) in peripheral blood cells were assessed for exposed residents of the Techa riverside villages as a function of individual exposure doses. The frequency of minisatellite mutations was found to be significantly higher in male gametes than in female ones; no clear-cut dose-effect relationship was traced.

[Genomic instability in the offspring of irradiated parents: facts and interpretations].

This review is devoted to genomic instability in the offspring of parents that were irradiated or treated with chemical mutagens. The evidence is presented, showing high frequency of cancer diseases and instability of the genome of somatic and germline cells in the offspring of radiation-exposed animals. Possible epigenetic mechanisms of these effects are considered, as well as their significance as components of genetic factors of radiation risk for humans.