Publications by authors named "I M Custers"
Study Question: Does offering the Pleasure&Pregnancy (P&P) programme rather than expectant management improve naturally conceived ongoing pregnancy rates in couples diagnosed with unexplained infertility?
Summary Answer: The P&P programme had no effect on the ongoing pregnancy rates of couples with unexplained infertility.
What Is Known Already: Underpowered studies suggested that face-to-face interventions targeting sexual health may increase pregnancy rates. The impact of an eHealth sexual health programme had yet to be evaluated by a large randomized controlled trial.
Biomedical data are generated and collected from various sources, including medical imaging, laboratory tests and genome sequencing. Sharing these data for research can help address unmet health needs, contribute to scientific breakthroughs, accelerate the development of more effective treatments and inform public health policy. Due to the potential sensitivity of such data, however, privacy concerns have led to policies that restrict data sharing.
View Article and Find Full Text PDFBackground: IVF and IUI with ovarian stimulation (IUI-OS) are widely used in managing unexplained infertility. IUI-OS is generally considered first-line therapy, followed by IVF only if IUI-OS is unsuccessful after several attempts. However, there is a growing interest in using IVF for immediate treatment because it is believed to lead to higher live birth rates and shorter time to pregnancy.
View Article and Find Full Text PDFArticle Synopsis
- The combination of whole-genome and transcriptome sequencing (WGTS) holds the potential to revolutionize how cancer is diagnosed and treated by providing a more precise and comprehensive testing method compared to traditional approaches.
- Despite its promise, there are significant challenges in integrating WGTS into mainstream healthcare, including issues of cost-effectiveness, affordability, and regulatory concerns.
- Current research highlights the clinical evidence supporting WGTS while emphasizing the need for better implementation strategies to enhance its use in various cancer types and improve patient outcomes.
Study Question: What are the experiences and the support and sexual advice needs of subfertile couples continuing to attempt natural conception after the diagnostic fertility work-up?
Summary Answer: Exploration of the experiences of couples showed that couples would have appreciated fertility clinic staff embedding expectant management into the fertility clinic trajectory, supportive staff with female and male patient interactions and advice on common experiences of peers and on managing their lifestyle, distress and subfertility-related sexual challenges.
What Is Known Already: Dutch and British professional guidelines advise newly diagnosed subfertile couples with a 'good prognosis' to continue to attempt natural conception and do not require fertility clinic staff to interact with patients. Fertility clinic staff and subfertile couples struggle to follow these guidelines as they feel an urgent need for action.