Publications by authors named "I M Chu"
Article Synopsis
- * The researchers created a 63-gene signature called Chemoresistance-Motility (CrM) to study how NMIBC evolves over time and used it to analyze 1,846 samples, revealing that early resistance stages are linked to increased cell movement and metastasis.
- * The study suggests that patients with high CrM scores have worse outcomes, ineffective responses to BCG and immune therapies, and identifies five alternative drugs to gemcitabine that may be effective, proposing a need for further validation of these findings.
Down-regulation of BCL11A protein reverses the fetal (HbF, αγ) to adult (HbA, αβ) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Because of reliance on ex vivo cell manipulation and marrow transplant, such therapies cannot lessen disease burden. To develop new small-molecule approaches, we investigated the state of BCL11A protein in erythroid cells.
View Article and Find Full Text PDFEarlier research suggested that psychotic experiences (PEs), the extended-psychosis phenotype, are associated with cognitive impairment. Recent studies, however, revealed more mixed findings, and patterns and magnitude of cognitive deficits in PEs remain uncertain. We aimed to systematically review and quantitatively synthesize estimates of cognitive functioning covering a wide array of domains in individuals with versus without PEs.
View Article and Find Full Text PDFStudy Objective: We aimed to characterize clinical features, comorbidities and polysomnographic characteristics of a large cohort of patients with narcolepsy.
Methods: We undertook a retrospective chart and polysomnographic review of all patients with a diagnosis of narcolepsy type 1 (NT1) or narcolepsy type 2 (NT2) seen within the Lehigh Valley Health Network between 2000 and 2022.
Results: We found 304 cases with a diagnosis of narcolepsy (52 NT1, 252 NT2), based on , third edition criteria.
Background: HIV self-testing (HIVST) may facilitate marginalised populations' uptake of HIV testing, but whether the extent of marginalisation challenges individual uptake of HIVST remains under-researched. We aim to explore the perspectives of multiply marginalised cis-gender gay, bisexual and other men who have sex with men (GBMSM) and trans women on whether HIVST might increase their uptake of HIV testing.
Methods: We reanalysed qualitative interview data from SELPHI (the UK's largest HIVST randomised trial) collected between 2017 and 2020 from marginalised populations, defined as people self-identifying as non-heterosexual, transgender, non-White ethnicity and/or with low educational attainment.