Publications by authors named "I M Cesari"
The adult worm -butanol extract (Sm-AWBE) has been previously shown to contain specific antigens that have been used for immunodiagnosis of schistosomiasis in solid phase alkaline phosphatase immunoassay (APIA) and western blot (WB) analyses. Sm-AWBE was also used in immunoprotection studies against a fatal live-cercariae challenge in experimental mouse vaccination (~43% protection). The Sm-AWBE fraction was prepared by mixing adult worm membranous suspensions with aqueous-saturated -butanol, centrifuging and recovering -butanol-resistant proteins in the aqueous phase.
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- The study focuses on understanding the biochemistry of head and neck tumors to gain insights into their metastatic potential, which is linked to high mortality rates.* -
- Researchers conducted RNA-Seq analyses on 5 different oral cancer cell lines to identify differentially expressed genes (DEGs) and their contributions to tumor invasion and metastatic progression.* -
- Key findings include the identification of 26 consistently expressed genes throughout tumor progression, two novel metastatic markers (PIGG and SLC8B1), and several genes (MYH14, ANGPTL4, PPARD, ENPP1) that could be targeted for pharmacological interventions.*
Schistosoma mansoni enzymes play important roles in host-parasite interactions and are potential targets for immunological and/or pharmacological attack. The aim of this study was to comparatively assess the presence of hydrolytic activities (phosphatases, glycosidases, aminopeptidases) in soluble (SF) and membrane (MF) fractions from different S. mansoni developmental stages (schistosomula 0 and 3h, juveniles, and adult worms of 28 and 45days-old, respectively), by using simple enzyme-substrate microassays.
View Article and Find Full Text PDFObjectives: Our objective was to evaluate the efficacy of probiotics and prebiotics in patients with Parkinson disease (PD) and constipation.
Methods: We conducted a tertiary setting, randomized, double-blind, placebo-controlled trial in patients with PD with Rome III-confirmed constipation based on 2-week stool diary data at baseline. Patients (n = 120) were randomly assigned (2:1) to either a fermented milk, containing multiple probiotic strains and prebiotic fiber, or placebo, once daily for 4 weeks.
Adult Schistosoma mansoni parasites have the capacity to degrade ingested host hemoglobin and other host plasma proteins by using a series of gut proteolytic enzymes, including cathepsin B; this enzyme is released to the host intravascular environment during regurgitations of adult worms. Cathepsin B becomes thus a circulating parasite component that has been shown to be specifically recognized as the Sm31 antigen by antibodies present in most S. mansoni infected patients.
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