Radiats Biol Radioecol
September 2004
It was shown that the experimental hypofunction of thyroid, induced by thyroidectomy and strong gamma-irradiation with a dose of 1 Gy lead to disturbance of function and structure of membranes of sarcoplasmic reticulum of myocites in rats. Introduction in vivo of L-thyroxine rose functional capacity of membranes with insignificaut changes in their lipid bilayer.
View Article and Find Full Text PDFThyroidectomy or administration of high activities (> 1.1 Mbq) of 131I to rats causes initial decrease in blood concentration of thyroid hormones which returns to the normal level. Administration of lower doses (< 1.
View Article and Find Full Text PDFThe alterations of amount of thyroid hormones have the characteristic dynamics that manifest itself by initial reduction with following partial or complete restoration of T3 and T4 concentration in rat blood after surgical or radioactive injuries of thyroid gland. Through presence of threshold of several dozens Gy for early dose-dependent hypothyroidism, the thyroid gland seems to be relatively radioresistant organ. Thyroid hormones concentration in blood has restored to normal level after experimental injuries which shows high restoration potential of thyroid gland function.
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