Publications by authors named "I M Appel"

Objectives: To describe the prevalence of pediatric acute respiratory distress syndrome (pARDS) and the characteristics of children with pARDS in South African PICUs.

Design: Observational multicenter, cross-sectional point-prevalence study.

Setting: Eight PICUs in four South African provinces.

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Article Synopsis
  • Maternal mortality is still a major issue in low-income countries, but high-quality antenatal care (ANC) can help mitigate this by reducing complications for mothers and newborns.
  • This study in rural Burkina Faso assessed the effectiveness of a performance-based financing (PBF) scheme aimed at enhancing ANC quality by comparing intervention and control districts.
  • While the PBF scheme increased facilities' readiness to provide ANC services, it didn't significantly improve the quality of clinical care or preventive measures, suggesting that stronger incentives are necessary to elevate patient care outcomes.
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Objectives: To evaluate the performance of the Pediatric Index of Mortality 3 as mortality risk assessment model.

Design: This prospective study included all admissions 30 days to 18 years old for 12 months during 2016 and 2017. Data gathered included the following: age and gender, diagnosis and reason for PICU admission, data specific for the Pediatric Index of Mortality 3 calculation, PICU outcomes (death or survival), and length of PICU stay.

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Background: Children seem relatively protected from serious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease, but little is known about children living in settings with high tuberculosis and human immunodeficiency virus (HIV) burden. This study reflects clinical data on South African children with SARS-CoV-2.

Methods: We collected clinical data of children aged <13 years with laboratory-confirmed SARS-CoV-2 presenting to Tygerberg Hospital, Cape Town, between 17 April and 24 July 2020.

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Background: Surgical craniosynostosis repair in children is associated with massive blood loss and significant transfusion of blood products. Fibrinogen concentrate is claimed to be useful in reducing blood loss and transfusion requirements.

Objective: We investigated whether prophylactic administration of fibrinogen concentrate will reduce blood loss and transfusion requirements during paediatric craniofacial surgery.

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