Publications by authors named "I M Alonso"

Cyclic peptides are valued synthetic targets in organic and medicinal chemistry. Herein, we report an efficient strategy for the synthesis of unnatural cyclic peptides via the Cu-catalyzed 1,3-dipolar cycloaddition of azomethylene ylides. Linear precursors of different lengths and bearing diverse amino acids (26 examples) are shown to be compatible with this method, affording good yields and complete -diastereoselectivities.

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Introduction: Fulvestrant demonstrated benefits in overall survival and progression-free survival in patients with advanced breast cancer, who are hormone receptor-positive and human epidermal growth factor receptor 2 negative. The characteristics, evolution, and survival of patients with hormone receptor-positive, HER2-negative breast cancer treated with fulvestrant were evaluated according to the national treatment coverage protocols of the National Resources Fund, with the aim of understanding the efficacy of fulvestrant in patients treated in usual clinical practice and comparing our results with those from pivotal studies.

Methods: A database from the National Resources Fund covering the period from 2009 to 2022 was used.

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Large Language Models (LLMs) have the potential of facilitating the development of Artificial Intelligence technology to assist medical experts for interactive decision support. This potential has been illustrated by the state-of-the-art performance obtained by LLMs in Medical Question Answering, with striking results such as passing marks in licensing medical exams. However, while impressive, the required quality bar for medical applications remains far from being achieved.

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We investigated decays of ^{51,52,53}K at the ISOLDE Decay Station at CERN in order to understand the mechanism of the β-delayed neutron-emission (βn) process. The experiment quantified neutron and γ-ray emission paths for each precursor. We used this information to test the hypothesis, first formulated by Bohr in 1939, that neutrons in the βn process originate from the structureless "compound nucleus.

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Article Synopsis
  • Gut microbiota significantly affects how patients respond to immune checkpoint inhibitors (ICIs) in cancer treatment, with a high level of specific bacteria linked to better outcomes.
  • Research shows that in patients with non-small cell lung cancer and melanoma, higher baseline levels of certain gut bacteria correlate with improved responses to ICIs.
  • The EXL01 strain of bacteria, currently in clinical trials for Inflammatory Bowel Disease, has been found to enhance T cell activation and restore anti-tumor responses when combined with ICIs, indicating its potential as an adjuvant therapy in cancer treatment.
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