Publications by authors named "I Lytrivi"
Purpose: Acute cellular (ACR) and antibody-mediated (AMR) rejection are risk factors for allograft loss in heart transplant (HT) recipients. Endomyocardial biopsy (EMB), although considered the gold standard for rejection surveillance, is invasive and has high interobserver variability. Noninvasive donor-derived cell-free DNA (dd-cfDNA) sampling has a high negative predictive value (NPV) for rejection in adults and is increasingly used in pediatrics.
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- Arrhythmias can cause severe heart issues in children, and when they are severe, heart transplantation (HTX) may be necessary, but this group has not been distinctively studied.
- *This study aimed to look at pediatric patients who needed HTX primarily due to malignant arrhythmia (MA) and how their outcomes compared to others on the list.
- *Out of thousands listed for HTX, only 63 patients (1.4%) had MA as the reason; although they were generally older and more likely to have had cardiac arrests, their chances of surviving and recovering after transplantation were similar to those without MA.
Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.
Pediatr Transplant
August 2024
Background: Acute kidney injury (AKI) is a common complication of pediatric heart transplant, with a subset of patients developing severe AKI requiring dialysis (AKI-D). We aimed to identify the epidemiology, risk factors, and outcomes of postoperative AKI-D in pediatric heart transplant recipients.
Methods: We retrospectively identified all pediatric first-time, single-organ heart transplants at our institution from 2014 to 2022.
The use of genetic testing has enhanced the diagnostic accuracy of heritable genetic cardiomyopathies. However, it remains unclear how genetic information is interpreted and incorporated into clinical practice for children with cardiomyopathy. The primary aim of this study was to understand how clinical practice differs regarding sequence variant classifications amongst pediatric cardiologists who treat children with cardiomyopathy.
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- This study explores the challenges faced by pediatric heart transplant (HT) recipients when transitioning to adult care, focusing on identifying risk factors for poor health outcomes.
- Researchers analyzed data from 72 patients who made this transition between 2011 and 2021, noting key factors such as medication adherence, psychiatric history, and age at transition.
- The findings emphasize the need for structured transition plans tailored to high-risk individuals to improve adherence and outcomes in adult HT care.