Publications by authors named "I Luque"
The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.
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- Trauma and pre-existing conditions (PECs) significantly influence the hospital and ICU length of stay (LOS) for older patients aged 55 and above, highlighting the need for focused care in this demographic.
- In a study of 5,168 trauma patients, certain PECs like congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and chronic renal failure (CRF) were found to increase H-LOS and ICU-LOS by several days.
- The findings suggest that recognizing and managing PECs in older trauma patients is crucial, as it can lead to more effective care and potentially shorter hospital stays.*
Background: The death of trauma patients with low injury severity scores (ISS) may not be fully explained by the severity of their injuries. Our objective was to evaluate preexisting conditions (PECs) that may contribute to the mortality rate of and hospital resources consumed by patients with low ISS.
Methods: Trauma patients with ISS <9 were selected from the National Trauma Database Bank [NTDB] [2019-21].
The Crimean-Congo haemorrhagic fever (CCHF) is a tropical viral zoonosis first reported in Spain with 17 detected cases since 2010-2024. Health professionals, including veterinarians, play a crucial role in controlling and preventing this disease. This study aimed to analyse and compare the knowledge, perceptions, and attitudes of veterinary students and professionals in Spain regarding CCHF and zoonoses in general.
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- The study focuses on distinguishing near-field (NF) and far-field (FF) electrograms (EGMs) to better identify critical areas for treating ventricular tachycardia (VT) during ablation procedures, using a new algorithm for EGM analysis.
- A multicenter study involving 30 patients was conducted, analyzing a massive dataset of EGMs to compare peak frequencies (PF) in different heart rhythms, revealing significant differences that could aid in pinpointing problematic heart circuits.
- Results indicated that a low-voltage area PF threshold of ≥200 Hz is effective for identifying VT isthmus, with findings suggesting that chronic amiodarone treatment can lower these PF values, potentially impacting treatment outcomes.