Publications by authors named "I Lopez de Heredia y Goya"

Background: Glenoid wear (GW) is a long-term complication after humeral head replacement (HHR) and is one of the major reasons for revision surgery. This study aimed to evaluate GW at >8 years of follow-up after HHR in patients with cuff tear arthropathy (CTA) by use of a modified classification of GW, to examine the relationship between GW and clinical outcomes, and to identify risk factors for GW progression.

Methods: This retrospective case-series study included 34 shoulders that were monitored for >8 years after HHR in patients with CTA (13 men and 21 women; mean age at surgery, 70.

View Article and Find Full Text PDF

Background: The aim of this study was to investigate glenoid wear in patients with humeral head replacement with a smaller humeral head, who were observed for >5 years, and to examine the relationship between radiographic changes and clinical outcome.

Methods: In this study, 41 shoulders of 41 patients (13 men, 28 women) were followed up for >5 years. The mean patient age at the time of surgery was 70.

View Article and Find Full Text PDF

Background: Although a loss of rotator cuff integrity leads to the superior migration of the humeral head, the parameters that characterize the anterolateral migration of the humeral head have not been established. The purpose of this study was to investigate the correlation between the translation of the humeral head scale (T-scale) and clinical outcomes of rotator cuff repair, as well as the correlation between the T-scale and radiologic parameters.

Methods: One hundred thirty-five consecutive patients with full-thickness rotator cuff tears underwent primary rotator cuff repair.

View Article and Find Full Text PDF

The costimulatory molecules in the B7-CD28 families are important in the regulation of T cell activation and tolerance. The butyrophilin family of proteins shares sequence and structure homology with B7 family molecules; however, the function of the butyrophilin family in the immune system has not been defined. In this study, we performed an analysis on multiple butyrophilin molecules and found that butyrophilin-like (BTNL)1 molecule functions to dampen T cell activation.

View Article and Find Full Text PDF
Article Synopsis
  • Statins, specifically lovastatin, can affect the immune system by reducing inflammation during a Candida albicans infection in mice.
  • The treatment with lovastatin shifted the immune response from a Th1 (pro-inflammatory) to a Th2 (anti-inflammatory) profile and increased regulatory T cell presence in the affected tissues.
  • The anti-inflammatory effects of lovastatin were linked to the expression of the chemokine CCL1, indicating that local chemokine regulation plays a crucial role in how statins modulate immune responses.
View Article and Find Full Text PDF