Publications by authors named "I Loeb"

Medication-related osteonecrosis of the jaw (MRONJ) poses a significant challenge considering the absence of a "gold standard" treatment. Cell-based therapy and tissue engineering offer promising therapeutic alternatives. This study aimed to harness the regenerative properties of adipose-tissue stromal vascular fraction (AT-SVF) and leukocyte-platelet-rich fibrin (L-PRF) for MRONJ treatment.

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Background: Head and neck cancer (HNC) is a complex affection. Nowadays, conventional treatments are associated with many side effects, reducing the patient's quality of life. Recent studies suggest that metformin, a first-line treatment for diabetes, could decrease cancer incidence and improve cancer-related survival rates.

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Children's treatment means a triangular relationship between the child, practitioner, and parent, with specific interactions influencing the procedure. The objective was to create and validate a hetero-rating scale of parental behavior and verify the correlation between child and parental behavior during pediatric dentistry sessions. Treatment sessions were recorded and evaluated, including 60 children representing three age groups.

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Article Synopsis
  • The study aimed to investigate how using antiangiogenic (AA) agents alongside antiresorptive (AR) agents affects the risk and severity of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients.
  • The research reviewed the medical records of 59 oncologic patients with MRONJ, comparing those treated with AR agents only to those also receiving AA agents, assessing various clinical factors.
  • Results indicated similar time intervals for MRONJ development in both groups, with no significant differences in the severity of the condition or treatment success rates.
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Purpose: The neutrophil-to-lymphocyte ratio (NLR) is the most widely biomarker used to assess the inflammatory system in various solid cancers. An elevated NLR has been reported to be associated with worse outcomes in head and neck squamous cell cancers (HNSCC). However, questions remain about the prognostic value of these findings in HNSCC patients with lung metastasis.

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