Publications by authors named "I Litt"
The use of osimertinib in the first-line (1L) setting is an effective treatment option for sensitizing -mutations (m+) and has significantly altered the standard of care practice for m+ disease in Canada. Unfortunately, acquired resistance to osimertinib is almost universal, and outcomes are disparate. Post-progression treatment patterns and the outcome of real-world Canadian m+ patients receiving 1L osimertinib were the focus of this retrospective review.
View Article and Find Full Text PDFArticle Synopsis
- Immune-related adverse events (irAEs) linked to immune checkpoint inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC) patients may enhance overall survival, though the relationship between irAE severity and survival is not well understood.
- This study analyzed data from 803 NSCLC patients treated with ICIs between March 2014 and November 2021 in Alberta, Canada, focusing on those who experienced clinically meaningful irAEs that affected their treatment regimen.
- The findings suggest a connection between the occurrence of irAEs and improved overall survival, with extensive data analysis conducted to determine factors influencing this outcome while avoiding biases in the evaluation.
Background: In solid organ transplant patients, non-participation in all aspects of the medical regimen is a prevalent problem associated with adverse consequences particularly in the adolescent and young adult (AYA) age group. This study is the first to evaluate the feasibility, utility and impact of a text messaging (TM) intervention to improve participation in laboratory testing in adolescent liver transplant patients.
Methods: AYA patients, aged 12 to 21 years, were recruited for a prospective pilot trial evaluating a TM intervention delivered over a 1-year period.
This study's purpose was to identify distinct publishing trajectories among 442 participants in three prominent mentored health services research career development programs (Veterans Affairs, National Institutes of Health, and Agency for Healthcare Research & Quality) in the 10 years after award receipt and to examine awardee characteristics associated with different trajectories. Curricula vitae (CVs) of researchers receiving awards between 1991 and 2010 were coded for publications, grants, and awardee characteristics. We found that awardees published at constant or increasing rates despite flat or decreasing rates of first-author publications.
View Article and Find Full Text PDFBackground: Much concern has been raised over pro-eating disorder (pro-ED) website communities, but little quantitative research has been conducted on these websites and their users.
Objective: To examine associations between levels of pro-ED website usage, disordered eating behaviors, and quality of life.
Methods: We conducted a cross-sectional, Internet-based survey of adult pro-ED website users.