Publications by authors named "I Leitner"
Background: Autoimmune hepatitis (AIH) is a rare entity; in addition, single-nucleotide polymorphisms (SNPs) may impact its course and outcome. We investigated liver-related SNPs regarding its activity, as well as in relation to its stage and treatment response in a Central European AIH cohort.
Methods: A total of 113 AIH patients (i.
Tangential flow filtration (TFF) is a central step in manufacturing of biopharmaceutics. Membrane clogging leads to decreased permeate flux, longer process time and potentially complete failure of the process. The effect of peristaltic pumping with tubings made of three different materials on protein particle formation during TFF was monitored via micro flow imaging, turbidity and photo documentation.
View Article and Find Full Text PDFObjectives: In the general population, increased afamin concentrations are associated with the prevalence and incidence of metabolic syndrome as well as type 2 diabetes. Although metabolic syndrome is commonly associated with nonalcoholic fatty liver disease (NAFLD), there exist no information on afamin and NAFLD.
Methods: Afamin concentrations were cross-sectionally measured in 146 Austrian patients with NAFLD, in 45 patients without NAFLD, and in 292 age- and sex-matched healthy controls.
Objective: To evaluate potential clinical parameters having an impact on visual outcome after endoscopic optic nerve decompression in acute optic neuropathy patients.
Methods: A retrospective chart review of patients with acute optic neuropathy, who underwent endoscopic optic nerve decompression between June 2001 and November 2018 at an academic center was performed. Patients were divided into groups according to visual improvement after surgical treatment (yes/no).
Article Synopsis
- A new definition for metabolic dysfunction-associated fatty liver disease (MAFLD) has been introduced, and a study was conducted to evaluate its impact on mortality among individuals aged 45 to 80 years.
- The research involved 4,718 subjects, analyzed their body mass index (BMI), and diagnosed fatty liver using ultrasound, discovering that the overall prevalence was 47.9% with various outcomes based on the presence or absence of MAFLD.
- The findings indicated that MAFLD did not significantly affect mortality rates over a median follow-up of 7.5 years, with similar survival rates across groups, suggesting that factors like age and existing health conditions played a larger role than MAFL