Publications by authors named "I Leigh"
Article Synopsis
- The study investigates the transition from actinic keratosis (AK) to cutaneous squamous cell carcinoma (cSCC), highlighting unclear mechanisms driving disease progression despite observed genetic mutations.
- RNA sequencing of 110 patient samples shows a progression from differentiated skin cells to a progenitor-like state, involving the suppression of genes responsible for skin cell differentiation and alterations in immune response.
- The research identifies a specific combination of tumor suppressor gene inactivation and Ras signaling activation that contributes to the development and progression of cSCC, providing insights for potential therapeutic interventions.
Background: Metastasis of cutaneous squamous cell carcinoma (cSCC) is uncommon. Current staging methods are reported to have sub-optimal performances in metastasis prediction. Accurate identification of patients with tumors at high risk of metastasis would have a significant impact on management.
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- The study explores how tumor-associated nerves (TANs) interact with cancer and the immune system, particularly focusing on their role in resistance to anti-PD-1 therapy in cutaneous squamous cell carcinoma (cSCC).
- Researchers found that cancer cells can damage TANs and myelin sheaths, leading to resistance against treatment.
- The presence of high rates of peri-neural invasion and immune-suppressive activity was associated with non-responders to anti-PD-1 therapy, indicating potential therapeutic targets for improving outcomes in similar cancers.
Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutaneous squamous cell carcinoma cells and identify the actin regulatory protein Mena as a key node in the adhesion complex network. Mena is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2, with which it interacts and co-localises at the nuclear envelope.
View Article and Find Full Text PDFBackground: Risk factors for cutaneous squamous cell carcinoma (cSCC) metastasis have been investigated only in relatively small data sets.
Objective: To analyze and replicate risk factors for metastatic cSCC.
Methods: From English and Dutch nationwide cancer registry cohorts, metastatic cases were selected and 1:1 matched to controls.