Publications by authors named "I Lacroix"
Cette note de recherche vise à présenter comment la science-fiction fut utilisée dans un projet de recherche pour coconstruire une vision commune de la robotique sociale favorisant la participation sociale des personnes aînées. Une recherche-action a été réalisée à l'aide de deux forums d'informateurs-clés regroupant des personnes aînées animés à partir d'extraits d'œuvres cinématographiques de science-fiction dans le but de stimuler leur réflexion. Une analyse de contenu thématique de ces forums a permis de mettre en évidence la contribution de l'usage de la science-fiction dans le cadre de cette démarche de recherche.
View Article and Find Full Text PDFIn March 2020, World Health Organization recognized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence as a public health emergency of international concern. One of the major preventative measures developed against coronavirus disease 2019 (COVID-19) was vaccines. To monitor their use and safety of vaccines from the first utilization in humans during clinical development phases to implementation for the general population, an enhanced national pharmacovigilance system was enabled by the French National Agency for Medicines and Health Products Safety in collaboration with the 30 Regional Pharmacovigilance Centres.
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- - Glucose-6-phosphate dehydrogenase (G6PD) deficiency, affecting 500 million people, impairs red blood cell antioxidant functions, raising the risk of hemolysis during oxidative stress, particularly during exercise.
- - A study using mice with a specific G6PD variant showed that, despite lower enzyme activity, these mice had better exercise performance and improved heart function post-exercise compared to normal mice.
- - Analysis revealed enhanced mitochondrial function and changes in energy metabolism and protein turnover, indicating that G6PD-deficient individuals might have a metabolic advantage during exercise, challenging existing beliefs about hemolytic risks.
In 2018, a significant neural tube defects (NTD) signal was reported after pre-conceptional exposure to dolutegravir, but was not confirmed in further analysis. Since 2019, dolutegravir-based regimen, an integrase inhibitor (INI), is recommended by WHO as the most-effective first-line therapy in all patients living with HIV. To explore the potential INI-related teratogenic effect, we searched disproportionate signals between exposure to INI-class drugs and congenital anomalies, compared to non-INI drugs, using the international pharmacovigilance database, VigiBase®.
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- Respiratory tract disorders are common in children, yet there is limited data on how respiratory medications are prescribed to them in France, leading to this study focusing on a specific cohort.
- Utilizing data from the POMME birth cohort, the study found that a significant majority (83.1%) of the 5956 children received prescriptions for respiratory medications, predominantly inhaled corticosteroids (ICSs).
- The findings indicated a notable rate of off-label prescriptions, especially in younger children, highlighting the need for further research and clinical guidance regarding appropriate medication usage in pediatric patients.