[Delayed clinical outcomes of coronary syndrome X: results of 15 year-long monitoring].

Clinical and pathomorphological outcomes of coronary syndrome X in 40 patients with intact subepicardial coronary arteries are analysed based on the results of 15 year-long monitoring. Primary examination revealed microvascular lesions in the coronary vessels in the form of idiopathic microangiopathy and plastic cardiomyocyte insufficiency confirmed by endomyocardial biopsy studies. The commonest undesirable outcomes after 15 years were myocardial infarction (7.

[The diagnostic significance of insulinemia in the evaluation of myocardial torpor and hibernation in patients with coronary artery disease].

The aim of the study was to estimate the diagnostic significance of changes in insulin blood level for the evaluation of torpor and hibernation of the myocardium in patients with coronary artery disease (CAD). The subjects, 60 CAD male patients aged 49.60 +/- 7.

[Possible role of hyperinsulinemia in pathogenesis of acute and chronic cardiac failure in patients with ischemic heart disease (data of clinical studies)].

Changes of blood insulin content were studied in patients with ischemic heart disease with various functional classes of acute and chronic heart failure and at different disease stages. It was established that latent hyperinsulinemia which became evident at induced myocardial ischemia was present on all stages of development of ischemic heart disease. In acute heart failure due to developed myocardial infarction hyperinsulinemia manifested in 58.

[The clinical conditions of the manifestation of hyperinsulinemia in patients with coronary heart disease].

The purpose of the study was to determine the conditions under which hyperinsulinemia (HI) is manifested in patients with coronary heart disease (CHD). Such factors as clinical manifestations of CHD, coronary atherosclerosis severity, and myocardial dysfunction severity, were taken into account. The subjects were 201 men aged 47.

[Relationships between changes of coronary blood flow, energy metabolism of the myocardium, and hyperinsulinemia in patients with ischemic heart disease].

The paper reviews current data on relationships between coronary blood flow, hemodynamics, and myocardial energy metabolism during phenomena of stunned and hibernating myocardium in patients with ischemic heart disease. These data has been obtained with various modern techniques including positron emission tomography with (18)F-flourodeoxyglucose, (11)C-palmitate and (11)C-acetate. Possible association of remodeling of cardiac energetic metabolism under conditions of chronic ischemia and hyperinsulinemia in patients at various stages of ischemic heart disease is interpreted as compensatory reaction to elevation of myocardial glucose requirements.