Diagnostic networks ensure efficiency in disease diagnosis. A descriptive study evaluated the network of public health laboratories (NPHL) in Minas Gerais State, Brazil, using diagnostic results for tegumentary leishmaniasis (TL) from the laboratory management system in 2017-2020. Out of 1,369 individuals analyzed, 704 (51.
View Article and Find Full Text PDFNatural conception in women after the age of 45 years is rare. The probability of successful pregnancy in this specific group of women after IVF and embryo transfer with autologous oocytes is also reduced. In addition, advanced maternal age is associated with an increased risk of aneuploidies and other associated complications during pregnancy.
View Article and Find Full Text PDFBackground: Soccer is the most recognized sports worldwide. It is a fertile ground for the use of metabolomics analyses, considering the multifactorial nature of soccer's physical demands on the body. Although scientific studies have tried using it to better understand the impacts of soccer into different contexts of the sport, no systematic review is available on metabolomics analyses in soccer athletes subjected to physical exertion interventions.
View Article and Find Full Text PDFOwing to their rapid cooling rate and hence loss-limited propagation distance, cosmic-ray electrons and positrons (CRe) at very high energies probe local cosmic-ray accelerators and provide constraints on exotic production mechanisms such as annihilation of dark matter particles. We present a high-statistics measurement of the spectrum of CRe candidate events from 0.3 to 40 TeV with the High Energy Stereoscopic System, covering 2 orders of magnitude in energy and reaching a proton rejection power of better than 10^{4}.
View Article and Find Full Text PDFBackground: Preliminary data suggest promising activity of loncastuximab tesirine in follicular lymphoma, and synergistic activity between rituximab-induced cytotoxicity and loncastuximab tesirine. In this study, we evaluated loncastuximab tesirine combined with rituximab for second-line and later treatment of follicular lymphoma.
Methods: We did a single-arm, investigator-initiated, phase 2 trial at Sylvester Comprehensive Cancer Center in Miami, FL, USA.