Publications by authors named "I L Rao"
Stylo (Stylosanthes guianensis) is a tropical legume that exhibits considerable tolerance to manganese (Mn) toxicity, which severely constrains plant growth in acidic soils. To elucidate the Mn detoxification mechanisms in stylo, this study investigated the excess Mn-regulated metabolic profile of stylo roots and examined the role of metabolic enzymes in Mn tolerance. Excess Mn triggered oxidative stress in the two stylo genotypes tested.
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- Chloride levels, often overlooked in critically ill patients, can indicate serious outcomes, such as acute kidney injury (AKI) and major adverse kidney events (MAKE30) in those with sepsis.
- In a study involving 400 sepsis patients, hypochloremia was found to be a significant risk factor for adverse kidney outcomes, with 32.3% of patients showing low chloride levels within 72 hours of ICU admission.
- Conversely, hyperchloremia did not demonstrate any significant association with MAKE30 or worsening AKI, suggesting that low chloride levels are more critical to monitor in sepsis patients.
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- Haematological abnormalities, particularly post-transplant anemia (PTA), are common among renal transplant recipients, with a peak prevalence of 98% in the first week post-surgery.
- Other issues included leukopenia, thrombocytopenia, and pancytopenia, often caused by medications and infections.
- Despite the high incidence of PTA initially, graft function was stable and similar among patients with and without anemia at six and 12 months post-transplant.
Objectives: The existing biomarkers used to promptly identify graft dysfunction after kidney transplantation lack consistency. Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker but its levels measured from serum and urine have demonstrated varying predictive values. Our study aimed to explore the potential of NGAL as a biomarker in predicting graft dysfunction in kidney transplant patients, including live and deceased donor recipients.
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- A significant portion of heart failure patients (around 30%) do not respond to cardiac resynchronization therapy (CRT), especially those with QRS durations between 120-149 ms who receive inconsistent benefits.
- A study evaluated the effectiveness of cardiac contractility modulation (CCM) in improving heart failure-related hospitalizations, left ventricular ejection fraction (LVEF), and quality of life in patients with this specific QRS duration.
- Results showed that CCM reduced hospitalizations by 72%, improved LVEF by 7%, and positively affected quality of life, with outcomes similar to those seen in patients with shorter QRS durations; mortality within the first year was not significantly different from predictions.