Publications by authors named "I L Kwee"
Article Synopsis
- CD37-targeted therapies, like naratuximab emtansine, have shown promise in treating lymphoma, demonstrating strong anti-tumor activity both alone and when combined with rituximab.
- The study investigated 54 lymphoma models, revealing that the drug's effectiveness varied with CD37 expression and discovered mechanisms of resistance related to genetic changes in cancer cells.
- Notable combinations with other drugs (anti-IL6, PI3Kδ inhibitors, and BCL2 inhibitors) improved the drug's efficacy in resistant lymphoma models, suggesting new treatment strategies for tougher cases.
Objectives: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease affecting mainly the axial skeleton. Peripheral involvement (arthritis, enthesitis and dactylitis) and extra-musculoskeletal manifestations, including uveitis, psoriasis and bowel inflammation, occur in a relevant proportion of patients. AS is responsible for chronic and severe back pain caused by local inflammation that can lead to osteoproliferation and ultimately spinal fusion.
View Article and Find Full Text PDFPurpose: The transmembrane protein CD37 is expressed almost exclusively in lymphoid tissues, with the highest abundance in mature B cells. CD37-directed antibody- and, more recently, cellular-based approaches have shown preclinical and promising early clinical activity. Naratuximab emtansine (Debio 1562, IMGN529) is an antibodydrug conjugate (ADC) that incorporates an anti-CD37 monoclonal antibody conjugated to the maytansinoid DM1 as payload.
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- - Fabry disease is a rare genetic disorder linked to the alpha-galactosidase gene, and while it can be managed with enzyme replacement therapy (ERT), understanding FN's molecular roots is essential for identifying biomarkers and drug targets.
- - The study involved RNA sequencing of biopsies from two cohorts of Fabry nephropathy patients and control individuals, revealing significant differences in gene expression associated with the disease and its response to ERT over time.
- - Despite some positive responses to early ERT—especially in gene expression patterns—many biological pathways, particularly in glomeruli and arteries, remained altered, leading to the identification of 69 potential drug repurposing candidates as adjunct treatments.
MYC is a pleiotropic transcription factor involved in cancer, cell proliferation, and metabolism. Its regulation and function in NK cells, which are innate cytotoxic lymphocytes important to control viral infections and cancer, remain poorly defined. Here, we show that mice deficient for Myc in NK cells presented a severe reduction in these lymphocytes.
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